| Most of these proteins fall into two distinct chromosomal distribution patterns : ( a ) kinetochore associated proteins ( Sin3A , PCAF , MYST and BAF 180 ) , which colocalize with metaphase kinetochores , but not any of the pericentric and other major heterochromatic regions ; and ( b ) heterochromatin associated proteins ( MeCP 2 , MBD 1 , MBD 2 , ATRX , HP1alpha , HDAC 1 , HDAC 2 , DNMT 1 and DNMT3b ) , which colocalize with centromeric / pericentric heterochromatin and all other major heterochromatic sites . ^^^ |