| Interacting proteins: Q9UIS9 and Q13111 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that MBD 1 partners with the p 150 subunit of chromatin assembly factor 1 ( CAF 1 ) , forming a multiprotein complex that also contains HP1alpha . ^^^ The MBD 1 CAF 1 p 150 interaction requires the methyl CpG binding domain of MBD 1 , and the association occurs in the C terminus of CAF 1 p 150 . ^^^ The two proteins colocalize to regions of dense heterochromatin in mouse cells , and overexpression of the C terminus of CAF 1 p 150 prevents the targeting of MBD 1 in these cells without disrupting global heterochromatin structure . ^^^ This interaction suggests a role for MBD 1 and CAF 1 p 150 in methylation mediated transcriptional repression and the inheritance of epigenetically determined chromatin states . . ^^^ |
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| Interacting proteins: Q9UIS9 and Q13111 |
Pubmed |
SVM Score :0.0 |
| Moreover , during DNA replication , MBD 1 recruits SETDB 1 to the large subunit of chromatin assembly factor CAF 1 to form an S phase specific CAF 1 / MBD1 / SETDB1 complex that facilitates methylation of H 3 K9 during replication coupled chromatin assembly . ^^^ |
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| Interacting proteins: Q9UIS9 and Q13111 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation analysis of methyl CpG binding domain containing proteins detected a greater amount of MeCP 2 , MBD 1 , and CAF 1 bound to the MGMT promoter in MGMT silenced cells . ^^^ |
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