| Interacting proteins: Q9UIS9 and P45973 |
Pubmed |
SVM Score :0.0 |
| The distribution of CGBP is distinct from the heterochromatin associated proteins MBD 1 , methyl CpG binding protein 2 , and HP1alpha . ^^^ |
|
| Interacting proteins: Q9UIS9 and P45973 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that MBD 1 partners with the p 150 subunit of chromatin assembly factor 1 ( CAF 1 ) , forming a multiprotein complex that also contains HP1alpha . ^^^ |
|
| Interacting proteins: Q9UIS9 and P45973 |
Pubmed |
SVM Score :0.0 |
| Methyl CpG binding domain 1 ( MBD 1 ) interacts with the Suv39h1 HP 1 heterochromatic complex for DNA methylation based transcriptional repression . ^^^ Here we show that histone H 3 methylase Suv39h1 and the methyl lysine binding protein HP 1 directly interact with MBD of MBD 1 in vitro and in cells . ^^^ These data indicate that MBD 1 may tether the Suv39h1 HP 1 complex to methylated DNA regions , suggesting the presence of a pathway from DNA methylation to the modifications of histones for epigenetic gene regulation . . ^^^ |
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| Interacting proteins: Q9UIS9 and P45973 |
Pubmed |
SVM Score :0.0 |
| Most of these proteins fall into two distinct chromosomal distribution patterns : ( a ) kinetochore associated proteins ( Sin3A , PCAF , MYST and BAF 180 ) , which colocalize with metaphase kinetochores , but not any of the pericentric and other major heterochromatic regions ; and ( b ) heterochromatin associated proteins ( MeCP 2 , MBD 1 , MBD 2 , ATRX , HP1alpha , HDAC 1 , HDAC 2 , DNMT 1 and DNMT3b ) , which colocalize with centromeric / pericentric heterochromatin and all other major heterochromatic sites . ^^^ |
|
| Interacting proteins: Q9UIS9 and P45973 |
Pubmed |
SVM Score :0.0 |
| Specific knockdown of either SUMO 2 / 3 or SUMO 1 induced dissociation of MCAF 1 , trimethyl H 3 K9 , and the HP 1 proteins from the MBD 1 containing heterochromatin foci , suggesting a requirement for SUMOs for heterochromatin assembly . ^^^ |
|
| Interacting proteins: Q9UIS9 and P45973 |
Pubmed |
SVM Score :0.0 |
| NA |
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