| The WICH complex , consisting of the ISWI type ATPase SNF2H and the Williams Syndrome Transcription Factor ( WSTF ) , binds to replication foci using PCNA , a key factor in DNA and chromatin replication and DNA repair , as an interaction platform . ^^^ Our model may provide an explanation for the long standing observation of a delay in chromatin `` maturation ' ' on newly replicated DNA , by connecting this delay with the action of PCNA bound WSTF ISWI , and highlights chromatin remodeling shortly after DNA replication as a critical point for regulation . . ^^^ |