| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| We found that Icat inhibits proliferation of colorectal tumor cells mutated in APC or beta catenin and hepatocellular carcinoma cells mutated in AXIN : By contrast , Icat did not inhibit growth of either normal or tumor cells containing the wild type APC , beta catenin , and Axin genes . ^^^ |
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| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB 1 , APC , ICAT and BTRC . ^^^ We investigated 37 malignant melanomas ( 15 primary tumors and 22 metastases ) for alterations of 4 genes encoding members of this pathway , i . e . , CTNNB 1 ( beta catenin gene , 3p22 . 1 ) , APC ( adenomatous polyposis coli gene , 5q22 . 2 ) , BTRC ( beta transducin repeat containing protein gene , 10q24 . 3 ) and ICAT ( inhibitor of beta catenin and Tcf 4 , 1p36 . 2 ) . ^^^ Taken together , our results indicate that the Wnt pathway may be altered in malignant melanomas by different mechanisms , including rare somatic mutations in CTNNB 1 , APC or ICAT , as well as low or absent expression of ICAT transcripts . . ^^^ |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| Remarkable structural diversity has been observed in beta catenin recognition of other cellular factors including APC , Tcf and ICAT , proteins that contribute to or compete with cadherin / catenin functioning . . ^^^ |
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| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| Several components of the Wnt / beta catenin pathway , such as APC , ICAT , LEF 1 and beta catenin are modified in melanoma tumors and cell lines , leading to activation of this signaling . ^^^ |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| The thermodynamics of beta catenin binding to E cadherin , Lef 1 , APC , axin , and the transcriptional inhibitor ICAT have been determined by isothermal titration calorimetry . ^^^ |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSA3 and P25054 |
Pubmed |
SVM Score :0.0 |
| NA |
|