| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| Mutant T53I , however , did not bind to CD 229 and CD 224 , suggesting that SH2D1A controls several critical signaling pathways in T and natural killer cells . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| The data suggest that signaling through SF 2000 , together with CD 150 , CD 244 , CD 84 , and CD 229 , is controlled by SAP and therefore contributes to the pathogenesis of XLP . . ^^^ Four of these family members ( CD 150 , CD 244 , CD 84 , CD 229 ) contain conserved tyrosine motifs in their cytoplasmic tails that enable them to bind intracellular signaling molecules SAP and EAT 2 . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| The cell surface expression of SAP binding receptor CD 229 is regulated via its interaction with clathrin associated adaptor complex 2 ( AP 2 ) . ^^^ Like other receptors of this family , CD 229 interacts with SAP / SH2D1a protein , mutation of which is responsible for the fatal 10 linked lymphoproliferative disease . ^^^ The integrity of this site was necessary for CD 229 internalization , but it was not involved in SAP recruitment . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| SAP is expressed in T cells , natural killer ( NK ) cells , and NKT cells , where it binds to the cytoplasmic domain of the surface receptor SLAM ( CD 150 ) and the related receptors , 2B4 ( CD 244 ) , CD 84 , Ly 9 ( CD 229 ) , NK T B antigen , and CD 2 like receptor activating cytotoxic T cells . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic tail of CD 229 binds to SAP , a protein that is defective in 10 linked lymphoproliferative syndrome . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| In addition to SLAM , SAP associates with several other cell surface receptors including 2B4 ( CD 244 ) , Ly 9 ( CD 229 ) , CD 84 and NTB A . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| The strain distribution pattern found for the Sap alleles was identical to that of alleles of Ly 9 in 43 individual RI strains , suggesting tight linkage with Ly 9 on mouse chromosome 1 . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| Levels of SAP were associated with alleles at the Ly 9 locus in two sets of RI strains : BXD ( C57BL / 6J 10 DBA / 2 ) and BXH ( C57BL / 6J 10 C3H / HeJ ) . ^^^ In the BXD strains 91 % of the genetic variation of SAP levels was accounted for by segregation at the Ly 9 locus while an additional 9 % was attributed to genetic factors unlinked to Ly 9 . ^^^ Because of background genetic variation it was not possible to detect any crossovers between Sap and Ly 9 . ^^^ However , in the BXD strains the linkage between Sap and Ly 9 appears to be quite close . ^^^ |
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| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| Here we show that SAP ( SH2D1A ) , an adapter protein responsible for the 10 linked lymphoproliferative disease , binds to the phosphorylated cytoplasmic tail of human but not mouse novel Ly 9 . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| Signaling pathways elicited via some of these receptors are believed to involve the Src homology 2 ( SH 2 ) domain containing cytoplasmic adaptor protein SLAM associated protein ( SAP ) , as it is recruited to SLAM , 2B4 , CD 84 , NTB A , and Ly 9 . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly 9 . ^^^ Here we demonstrate that SAP is required for phosphorylation of both SLAM and Ly 9 in thymocytes and peripheral T cells . ^^^ Our results demonstrate that SAP is an adaptor that bridges SLAM and Ly 9 with Src like protein tyrosine kinases ( PTKs ) , and has the ability to activate FynT . . ^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.95348316 |
| We have identified significant phenotypic differences between Ly 9 / mice as compared with both SLAM / and SAP / mice . 0.95348316^^^ |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9HBG7 and O60880 |
Pubmed |
SVM Score :0.0 |
| NA |
|