| Interacting proteins: Q9H461 and O75581 |
Pubmed |
SVM Score :0.0 |
| WNT family ligands transduce signals through FZD 1 , FZD 2 , FZD 3 , FZD 4 , FZD 5 , FZD 6 , FZD 7 , FZD 8 , FZD 9 , FZD 10 , LRP 5 , LRP 6 , ROR 1 , ROR 2 and RYK . ^^^ |
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| Interacting proteins: Q9H461 and O75581 |
Pubmed |
SVM Score :0.0 |
| WNT family proteins bind to transmembrane proteins FZD 1 , FZD 2 , FZD 3 , FZD 4 , FZD 5 , FZD 6 , FZD 7 , FZD 8 , FZD 9 , FZD 10 , LRP 5 , LRP 6 , ROR 1 , ROR 2 , RYK , and also secreted proteins SFRP 1 , SFRP 2 , SFRP 3 , SFRP 4 , SFRP 5 , and DAND 4 ( CER 1 ) . ^^^ |
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| Interacting proteins: Q9H461 and O75581 |
Pubmed |
SVM Score :0.0 |
| In this study , we provide several lines of evidence that the mouse Cristin / R spondin family proteins function as Fzd 8 and LRP 6 receptor ligands and induce the canonical Wnt / beta catenin signaling pathway , leading to TCF dependent gene activation . ^^^ Third , Cristin / R spondin proteins physically interacted with the extracellular domains of the LRP 6 and Fzd 8 receptors in vivo and in vitro . ^^^ Interestingly , unlike canonical Wnt ligands , Cristin / R spondin failed to form a ternary complex with both LRP 6 and Fzd 8 receptors , suggesting that R spondin may activate the canonical Wnt signaling pathway by different mechanisms . ^^^ |
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