| Interacting proteins: Q9BY43 and Q8WUM4 |
Pubmed |
SVM Score :0.87626995 |
| The ALG 2 interacting protein Alix associates with CHMP4b , a human homologue of yeast Snf 7 that is involved in multivesicular body sorting . 0.87626995^^^ The interaction of Alix with CHMP4b was confirmed by a glutathione S transferase pull down assay and by co immunoprecipitation experiments . 0.87411081^^^ |
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| Interacting proteins: Q9BY43 and Q8WUM4 |
Pubmed |
SVM Score :0.0 |
| Whereas mapping experiments showed that the N terminus of AIP 1 containing both a Bro 1 and an alpha helical domain were required for interaction with hSnf 7 1 , Snf 7 1 did not interact with another human Bro 1 containing molecule , rhophilin 2 . ^^^ |
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| Interacting proteins: Q9BY43 and Q8WUM4 |
Pubmed |
SVM Score :0.0 |
| CHMP4b is a major binding partner of the ALG 2 interacting protein Alix among the three CHMP 4 isoforms . ^^^ The ALG 2 interacting protein Alix has recently been demonstrated to associate with CHMP4b that is a human homologue of yeast Snf7p ( also named Vps32p ) and a member of the family of small coiled coil proteins named CHMP implicated in playing roles in multivesicular body sorting . ^^^ Further , using recombinant glutathione S transferase ( GST ) fusion protein of truncated Alix ( amino acids 1 423 ) and thioredoxin tagged CHMP 4 proteins , the direct interactions were detected by a GST pull down assay , where CHMP4b showed a stronger interaction than other CHMP 4 isoforms . ^^^ These results suggest that CHMP4b is a major binding partner of Alix among the three CHMP 4 isoforms . . ^^^ |
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| Interacting proteins: Q9BY43 and Q8WUM4 |
Pubmed |
SVM Score :0.0 |
| Alix / apoptosis linked gene 2 ( ALG 2 ) interacting protein 10 is an adaptor protein involved in the regulation of the endolysosomal system through binding to endophilins and to endosomal sorting complexes required for transport ( ESCRT ) proteins , TSG 101 and CHMP4b . ^^^ On the other hand , expression of Alix mutants lacking the ALG 2 or the CHMP4b binding sites prevents early programmed cell death in cervical motoneurons at day 4 . 5 of chick embryo development . ^^^ |
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| Interacting proteins: Q9BY43 and Q8WUM4 |
Pubmed |
SVM Score :0.0 |
| Interactions of CHMP 6 with another ESCRT 3 component CHMP4b / Shax [ Snf 7 ( sucrose non fermenting 7 ) homologue associated with Alix ] 1 , one of three paralogues of human Vps32 / Snf7 , and with EAP 20 ( ELL associated protein 20 ) , a human counterpart of yeast Vps 25 and component of ESCRT 2 , were observed by co immunoprecipitation of epitope tagged proteins expressed in HEK 293 cells . ^^^ |
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| Interacting proteins: Q9BY43 and Q8WUM4 |
Pubmed |
SVM Score :0.0 |
| NA |
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