| SKD 1 ( E235Q ) , a dominant negative form of the AAA type ATPase SKD 1 that plays critical roles in the endocytic pathway , was co immunoprecipitated with CHMP4b . ^^^ Furthermore , CHMP4b co localized with SKD 1 ( E235Q ) as punctate patterns in the perinuclear area , and Alix was induced to exhibit dot like distributions overlapped with SKD 1 ( E235Q ) in HeLa cells . ^^^ |