| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Here we show that the imidazoquinolines activate immune cells via the Toll like receptor 7 ( TLR 7 ) MyD 88 dependent signaling pathway . ^^^ In response to the imidazoquinolines , neither MyD 88 nor TLR 7 deficient mice showed any inflammatory cytokine production by macrophages , proliferation of splenocytes or maturation of dendritic cells . ^^^ Imidazoquinoline induced signaling events were also abolished in both MyD 88 and TLR 7 deficient mice . . ^^^ |
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| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| TLR 7 and MyD 88 deficient immune cells fail to proliferate or produce cytokines in response to loxoribine , and genetic complementation of TLR 7 deficient cells with murine or human TLR 7 confers responsiveness . ^^^ Subsequently we show that cellular activation by loxoribine and resiquimod ( R 848 ) , a stimulus for TLR 7 and TLR 8 , depends on acidification and maturation of endosomes and targets MyD 88 to vesicular structures with lysosomal characteristics . ^^^ |
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| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| The resulting predictions show the presence of one or more counterparts for the human TLR 1 , TLR 2 , TLR 3 , TLR 4 , TLR 5 , TLR 7 , TLR 8 , TLR 9 , IL 1R and IL 18R genes and one copy of the adaptor genes MyD 88 , MAL , TRIF and SARM . ^^^ |
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| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Here , we show that this requires endosomal recognition of influenza genomic RNA and signaling by means of Toll like receptor 7 ( TLR 7 ) and MyD 88 . ^^^ |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in either the TLR 7 or the TLR adaptor protein MyD 88 demonstrated reduced responses to in vivo infection with vesicular stomatitis virus . ^^^ |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Toll like receptor ( TLR ) activation is central to immunity , wherein the activation of the TLR 9 subfamily members TLR 9 and TLR 7 results in the robust induction of type 1 IFNs ( IFN alpha / beta ) by means of the MyD 88 adaptor protein . ^^^ |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Stimulation of TLR 7 or TLR 9 leads to type 1 IFN responses through the MyD 88 pathway . ^^^ |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Such responses were severely impaired in TLR 9 / and myeloid differentiation factor 88 ( MyD 88 ) / , but not in TLR 2 , TLR 4 , TLR 7 , or Toll / interleukin 1 receptor domain containing adaptor inducing interferon beta / mice . ^^^ |
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| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate that MyD 88 , interleukin 1 receptor associated kinase 1 , and tumor necrosis factor receptor associated factor 6 are required for the activation of IRF 5 and IRF 7 in the TLR 7 signaling pathway . ^^^ |
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| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| IFN alpha priming led to increased expression of Toll like receptor 3 ( TLR 3 ) , TLR 7 , TLR 8 , MyD 88 , TRIF , and IFN regulatory factor 7 ( IRF 7 ) genes and enhanced influenza induced phosphorylation and DNA binding of IRF 3 . ^^^ |
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| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| In MCF 7 , mRNA for LL 37 , inhibitor of kappaBalpha , NFkappaBp 65 , Tollip , MyD 88 , IL 1R associated kinase , and TLR 7 were up regulated . ^^^ |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| TLR 7 ligand prevents allergen induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD 88 dependent and MK 2 independent pathway . ^^^ |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| IFN alpha and TNF alpha induced the expression of the RIG 1 , TLR 3 , MyD 88 , TRIF , and IRF 7 genes , whereas no detectable TLR 7 and TLR 8 was seen in A 549 cells . ^^^ |
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| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Similarly , the activation of transcription factors and chemokine genes is induced in these mouse cells through primarily TLR 3 signaling pathway , but not TLR 7 or other MyD 88 mediated pathways following TMEV infection . ^^^ |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NYK1 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|