| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| The intracellular signaling cascade involves recruitment of two IL 1R associated kinases , IRAK 1 and IRAK 2 , and the adapter protein MyD 88 , events which are dependent on the intracellular domain of membrane bound IL 1RAcP ( mIL 1RAcP ) . ^^^ |
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| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Binding of IL 1 to its receptor results in rapid assembly of a membrane proximal signalling complex that consists of two different receptor chains ( IL 1Rs ) , IL 1RI and IL 1RAcP , the adaptor protein MyD 88 , the serine / threonine kinase IRAK and a new protein , which we have named Tollip . ^^^ |
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| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| In hypothalamic neurons , binding of IL 1beta to IL 1RI mediates transcription dependent changes that depend on the recruitment of the cytosolic adaptor protein myeloid differentiation primary response protein 88 ( MyD 88 ) to the IL 1RI / IL 1 receptor accessory protein ( IL 1RAcP ) complex through homomeric Toll / IL 1 receptor ( TIR ) TIR interactions . ^^^ Through design and synthesis of bifunctional TIR mimetics that disrupt the interaction of MyD 88 with the IL 1RI / IL 1RAcP complex , we analyzed the involvement of MyD 88 in the signaling of IL 1beta in anterior hypothalamic neurons . ^^^ We show here that IL 1beta mediated activation of the protein tyrosine kinase Src depended on a MyD 88 interaction with the IL 1RI / IL 1RAcP complex . ^^^ The activation of the protein kinase Akt / PKB depended on the recruitment of the p 85 subunit of PI3K to IL 1RI and independent of MyD 88 association with the IL 1RI / IL 1RAcP complex . ^^^ |
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| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Strikingly , only mutations of residues 195 197 eliminated the TIR TIR interaction of MyD 88 and IL 1 receptor accessory protein ( IL1RAcP ) , whereas substitution of neighboring canonical Pro 200 by His was without effect . ^^^ |
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| Interacting proteins: Q9NPH3 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Resting human monocytes expressed high levels of IL 1RII , IL 1R AcP , MyD 88 and rsc 786 , whereas low levels of IL 1RI and T1 / ST2 were present . ^^^ |
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