Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.52984848
Interferon alpha induction through Toll like receptors involves a direct interaction of IRF 7 with MyD 88 and TRAF 6 . 0.52984848^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.8576598
Here , we demonstrate that the transcription factor IRF 7 interacts with MyD 88 to form a complex in the cytoplasm . 0.8576598^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
We also demonstrate that MyD 88 , interleukin 1 receptor associated kinase 1 , and tumor necrosis factor receptor associated factor 6 are required for the activation of IRF 5 and IRF 7 in the TLR 7 signaling pathway . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
Using mice deficient in the Irf 7 gene ( Irf 7 / mice ) , we show that the transcription factor IRF 7 is essential for the induction of IFN alpha / beta genes via the virus activated , MyD 88 independent pathway and the TLR activated , MyD 88 dependent pathway . ^^^ Viral induction of MyD 88 independent IFN alpha / beta genes is severely impaired in Irf 7 / fibroblasts . ^^^ Consistently , Irf 7 / mice are more vulnerable than Myd 88 / mice to viral infection , and this correlates with a marked decrease in serum IFN levels , indicating the importance of the IRF 7 dependent induction of systemic IFN responses for innate antiviral immunity . ^^^ Furthermore , robust induction of IFN production by activation of the TLR 9 subfamily in plasmacytoid dendritic cells is entirely dependent on IRF 7 , and this MyD 88 IRF 7 pathway governs the induction of CD8+ T cell responses . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
Spatiotemporal regulation of MyD 88 IRF 7 signalling for robust type 1 interferon induction . ^^^ It is absolutely dependent on the transcription factor IRF 7 , which interacts with and is activated by the adaptor MyD 88 . ^^^ How plasmacytoid dendritic cells , but not other cell types ( such as conventional dendritic cells ) , are able to activate the MyD 88 IRF 7 dependent IFN induction pathway remains unknown . ^^^ Here we show that the spatiotemporal regulation of MyD 88 IRF 7 signalling is critical for a high level IFN induction in response to TLR 9 activation . ^^^ The IFN inducing TLR 9 ligand , A / D type CpG oligodeoxynucleotide ( CpG A ) , is retained for long periods in the endosomal vesicles of plasmacytoid dendritic cells , together with the MyD 88 IRF 7 complex . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
IFN alpha priming led to increased expression of Toll like receptor 3 ( TLR 3 ) , TLR 7 , TLR 8 , MyD 88 , TRIF , and IFN regulatory factor 7 ( IRF 7 ) genes and enhanced influenza induced phosphorylation and DNA binding of IRF 3 . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
Two members of the IFN regulatory factor ( IRF ) family of transcription factors , IRF 5 and IRF 7 , interact with MyD 88 and induce proinflammatory cytokines and type 1 IFNs , respectively . ^^^ IRF 4 mRNA is induced by TLR activation , and IRF 4 competes with IRF 5 , but not with IRF 7 , for MyD 88 interaction . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
New insights into the activation of IRF family members , notably IRF 3 , IRF 5 and IRF 7 , have been obtained , and interesting spatiotemporal aspects of signalling by MyD 88 leading to IRF 7 activation revealed . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
IFN alpha and TNF alpha induced the expression of the RIG 1 , TLR 3 , MyD 88 , TRIF , and IRF 7 genes , whereas no detectable TLR 7 and TLR 8 was seen in A 549 cells . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
TLR7 / 9 induced IFN alpha induction depends on a molecular complex that contains a TLR adaptor , MyD 88 , and IFN regulatory factor 7 ( IRF 7 ) ( refs 10 14 ) , but the underlying molecular mechanisms are as yet unknown . ^^^ Kinase deficient IKK alpha inhibited the ability of MyD 88 to activate the Ifna promoter in synergy with IRF 7 . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
Shortly after TLR 9 engagement , colocalization of Opn 1 and the adaptor molecule MyD 88 was associated with induction of transcription factor IRF 7 dependent IFN alpha gene expression , whereas deficient expression of Opn 1 was associated with defective nuclear translocation of IRF 7 in pDCs . ^^^
Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
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Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
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Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
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Interacting proteins: Q92985 and Q99836 Pubmed SVM Score :0.0
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