Interacting proteins: Q13568 and Q99836 |
Pubmed |
SVM Score :0.64328711 |
We also provide evidence that IRF 5 interacts with and is activated by MyD 88 and TRAF 6 , and that TLR activation results in the nuclear translocation of IRF 5 to activate cytokine gene transcription . 0.64328711^^^ |
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Interacting proteins: Q13568 and Q99836 |
Pubmed |
SVM Score :0.0 |
We also demonstrate that MyD 88 , interleukin 1 receptor associated kinase 1 , and tumor necrosis factor receptor associated factor 6 are required for the activation of IRF 5 and IRF 7 in the TLR 7 signaling pathway . ^^^ |
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Interacting proteins: Q13568 and Q99836 |
Pubmed |
SVM Score :0.0 |
Two members of the IFN regulatory factor ( IRF ) family of transcription factors , IRF 5 and IRF 7 , interact with MyD 88 and induce proinflammatory cytokines and type 1 IFNs , respectively . ^^^ IRF 4 mRNA is induced by TLR activation , and IRF 4 competes with IRF 5 , but not with IRF 7 , for MyD 88 interaction . ^^^ |
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Interacting proteins: Q13568 and Q99836 |
Pubmed |
SVM Score :0.0 |
New insights into the activation of IRF family members , notably IRF 3 , IRF 5 and IRF 7 , have been obtained , and interesting spatiotemporal aspects of signalling by MyD 88 leading to IRF 7 activation revealed . ^^^ |
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