| Interacting proteins: Q99836 and Q13158 |
Pubmed |
SVM Score :0.0 |
| TLR 2 signals for apoptosis through MyD 88 via a pathway involving Fas associated death domain protein ( FADD ) and caspase 8 . ^^^ Moreover , MyD 88 binds FADD and is sufficient to induce apoptosis . ^^^ |
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| Interacting proteins: Q99836 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Another DD containing protein , Fas associated death domain ( FADD ) , also binds MyD 88 through respective DD DD interactions . ^^^ |
|
| Interacting proteins: Q99836 and Q13158 |
Pubmed |
SVM Score :0.0 |
| This suggests , that Yersinia induced apoptosis involves a proapoptotic signal relay through MyD 88 and IRAK 2 , which potentially targets the Fas associated death domain protein / caspase 8 apoptotic pathway , whereas IRAK 1 and TRAF 6 counteract the bacteria induced cytotoxic response by signaling macrophage survival . . ^^^ |
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| Interacting proteins: Q99836 and Q13158 |
Pubmed |
SVM Score :0.0 |
| Dominant negative forms of MyD 88 and FADD , but not IRAK 4 , reduced the cytocidal activity of the lipoproteins . ^^^ These findings suggest that mycoplasmal lipoproteins can trigger TLR 2 and TLR 6 mediated sequential bifurcate responses : NF kappa B activation as an early event , which is partially mediated by MyD 88 and FADD ; and apoptosis as a later event , which is regulated by p 38 MAPK as well as by MyD 88 and FADD . . ^^^ |
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