| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Activation of NF kappaB by Mal requires IRAK 2 , but not IRAK , whereas MyD 88 requires both IRAKs . ^^^ |
|
| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Receptor proximal proteins involved include the adapter MyD 88 , IRAK , IRAK 2 , Tollip , TRAF 6 and TAK 1 . ^^^ |
|
| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| IRAK 2 is also capable of associating directly with MyD 88 by distinct regions . ^^^ |
|
| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| However , IRAK1c retains the ability to strongly interact with IRAK 2 , MyD 88 , Tollip , and TRAF 6 . ^^^ |
|
| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| IRAK ( Pelle ) family member IRAK 2 and MyD 88 as proximal mediators of IL 1 signaling . ^^^ Two additional proximal mediators were identified that are required for IL 1R induced NF kappaB activation : IRAK 2 , a Pelle family member , and MyD 88 , a death domain containing adapter molecule . ^^^ Therefore , IRAK 2 and MyD 88 may provide additional therapeutic targets for inhibiting IL 1 induced inflammation . . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| In transient cotransfection experiments , dominant negative mutants of the IL 1 signaling pathway , including MyD 88 , IRAK , IRAK 2 , and TRAF 6 inhibited both IL 1 and LPS induced NF kappaB luciferase activity . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| The intracellular signaling cascade involves recruitment of two IL 1R associated kinases , IRAK 1 and IRAK 2 , and the adapter protein MyD 88 , events which are dependent on the intracellular domain of membrane bound IL 1RAcP ( mIL 1RAcP ) . ^^^ Furthermore , we demonstrate that human HepG 2 hepatoma cells express both mIL 1RAcP and sIL 1RAcP and that signal transduction in these cells is mediated through IRAK 1 , IRAK 2 , and MyD 88 . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| The signalling pathways involve two adapter proteins , MyD 88 and Tollip , which via two IL 1 receptor associated kinases ( IRAK and IRAK 2 ) activate transcription factors such as nuclear factor kappa B and protein kinases such as p 38 mitogen activated protein kinase . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the activation of p 38 MAPK caused by overexpressing active RasVHa could not be inhibited using dominant negative mutants of MyD 88 , IRAK , or IRAK 2 , or TRAF 6 , but could be inhibited by dominant negative MKK 3 or MKK 6 . ^^^ Active RasVHa associated with IRAK , IRAK 2 , and TRAF 6 , but not MyD 88 . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Signal transduction between MyD 88 and TRAF 6 is known to involve the serine threonine kinase IL 1 receptor associated kinase 1 ( IRAK 1 ) and two homologous proteins , IRAK 2 ( ref . 12 ) and IRAK M . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Dominant negative myeloid differentiation factor 88 ( MyD 88 ) or IL 1R associated kinase ( IRAK ) 2 diminished LPS induced apoptosis in YopP transfected macrophages , suggesting implication of MyD 88 and IRAK 2 in signaling cell death . ^^^ This suggests , that Yersinia induced apoptosis involves a proapoptotic signal relay through MyD 88 and IRAK 2 , which potentially targets the Fas associated death domain protein / caspase 8 apoptotic pathway , whereas IRAK 1 and TRAF 6 counteract the bacteria induced cytotoxic response by signaling macrophage survival . . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| Receptor proximal proteins involved in signalling by all TLRs include the adapter MyD 88 , 3 IRAKs ( IRAK 4 , IRAK and IRAK 2 ) , Tollip , Traf 6 and TAK 1 . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| In this paper , we report that IRAK 2 and MyD 88 , but not IRAK 1 , interact physically with Akt , as demonstrated by co immunoprecipitation and pull down experiments . ^^^ We also demonstrate that Akt activity is necessary for IL 1 dependent NF kappaB transactivation , since a kinase defective mutant of Akt impairs IRAK 2 and MyD 88 dependent , but not IRAK 1 dependent , NF kappaB activity , as monitored by a gene reporter assay . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of many TLR related genes ( ICAM 1 , CD 14 , MyD 88 , LY 96 , TRIF , TICAM 2 , TIRAP , CD 83 , SOCS 1 , TNFAIP 3 , TOLLIP , IRAK 1 , IRAK 2 , IRAK 4 , and TRAF 6 ) was successfully detected in all of the tissues and cell lines . ^^^ |
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| Interacting proteins: O43187 and Q99836 |
Pubmed |
SVM Score :0.0 |
| In addition , co transfection of vectors expressing fluorescent protein fused TRAF 6 and non fluorescent MyD 88 , IRAK 1 and IRAK 2 revealed an inverse correlation between increased sequestosome formation and activation of both PI 3 kinase and NF kappaB . ^^^ |
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