| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :1.0014975 |
| In addition , CDCrel 1 , a synaptic vesicle associated protein , was found to be a substrate for Parkin as an E 3 . 1.0014975^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| We found that CDCrel 1 , a synaptic vesicle protein , was a candidate substrate of parkin protein . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| Parkin functions as an E 2 dependent ubiquitin protein ligase and promotes the degradation of the synaptic vesicle associated protein , CDCrel 1 . ^^^ We also identify and show that the synaptic vesicle associated protein , CDCrel 1 , interacts with Parkin through its ring finger domains . ^^^ Furthermore , Parkin ubiquitinates and promotes the degradation of CDCrel 1 . ^^^ Familial linked mutations disrupt the ubiquitin protein ligase function of Parkin and impair Parkin and CDCrel 1 degradation . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| In addition , the gene encoding this protein maps to a locus often deleted in velo cardiofacial and DiGeorge syndromes , and CDCrel 1 has recently been shown to be a direct target of the E 3 ubiquitin ligase activity of Parkin , a causative agent in autosomal recessive forms of Parkinson ' s disease . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| Several substrates for parkin have been identified ( CDCrel 1 , o glycosylated alpha synuclein , parkin associated endothelin like cell receptor , and synphilin ) . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| A number of candidate substrates have been identified for parkin ubiquitin ligase action including CDCrel 1 , o glycosylated alpha synuclein , Pael R , and synphilin 1 . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| Secondly , putative substrates interacting with parkin include a synaptic vesicle associated GTPase named CDCrel 1 ; a G protein coupled receptor named Pael ; a novel from of alpha synuclein ; and an alpha synuclein interacting protein synphilin 1 . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| The specific recruitment of parkin was dependent on concentration and duration of the treatment , and was accompanied by the centrosomal accumulation of ubiquitinated proteins and CDCrel 1 , a substrate of parkin . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| Steady state levels of CDCrel 1 , synphilin 1 , and alpha synuclein , which were identified previously as substrates of the E 3 ubiquitin ligase activity of parkin , are unaltered in parkin / brains . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| AR JP associated parkin mutations inhibit ubiquitination and degradation of CDCrel 1 and other parkin target proteins . ^^^ These results show that CDCrel 1 overexpression exerts dopamine dependent neurotoxicity and suggest that inhibition of dopamine secretion by CDCrel 1 may contribute to the development of AR JP . . ^^^ Dopamine dependent neurodegeneration in rats induced by viral vector mediated overexpression of the parkin target protein , CDCrel 1 . ^^^ Parkin functions as a ubiquitin protein ligase in the degradation of several proteins , including the neuron specific septin CDCrel 1 . ^^^ AR JP associated parkin mutations inhibit ubiquitination and degradation of CDCrel 1 and other parkin target proteins . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| Consistent with these findings , we further observed that degradation of CDCrel 1 , a parkin substrate , was facilitated by overexpression of parkin protein . ^^^ However , co transfection of Nrdp 1 with parkin reversed the effects of parkin on CDCrel 1 degradation . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the up regulation of several members of the membrane associated guanylate kinase family of synaptic scaffold proteins and several septins , including the Parkin substrate cell division control related protein 1 ( CDCRel 1 ) , may contribute to the abnormalities in neurotransmitter release previously observed in parkin KO mice . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| Septin 5 , a parkin substrate , is a vesicle and membrane associated protein that plays a significant role in inhibiting exocytosis . ^^^ As loss of function mutations of parkin are the principal cause of a familial Parkinson ' s disease , a prevailing hypothesis is that the loss of parkin activity results in accumulation of Septin 5 which confers neuron specific toxicity in SN DAergic neurons . ^^^ In our well characterized DAergic SN 4741 cell model , acute accumulation of elevated levels of Septin 5 , but not synphilin 1 ( another parkin substrate ) , resulted in cytotoxic cell death that was markedly reduced by parkin co transfection . ^^^ A transgenic mouse model expressing a dominant negative parkin mutant accumulated moderate levels of Septin 5 in SN DAergic neurons . ^^^ |
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| Interacting proteins: Q99719 and O60260 |
Pubmed |
SVM Score :0.0 |
| SEPT5 _ v2 is highly homologous to another septin , SEPT 5 , which was recently identified as a target for parkin mediated ubiquitination . ^^^ |
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