| Pull down and co immunoprecipitation studies with deletion mutants confirmed that EEN interacted directly with BPGAP 1 via its Src homology 3 ( SH 3 ) domain binding to the proline rich region 182 PPPRPPLP 189 of BPGAP 1 , with prolines 184 and 186 being indispensable for this interaction . 1.2266391^^^ |