BPGAP 1 is a novel RhoGAP that co ordinately regulates pseudopodia and cell migration through the interplay of its BNIP 2 and Cdc42GAP homology domains serving as a homophilic / heterophilic interaction device , an enzymic RhoGAP domain that inactivates RhoA and a proline rich region that binds the Src homology 3 domain of cortactin . ^^^ |