| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The electrophoretic mobility of histones H 3 , H2b and H2a from three evolutionally unrelated sources ( trout and chicken erythrocytes and calf thymus ) is increased and that for histones H 1 and H 5 is decreased with respect to histone H 4 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| These results , together with those concerning histone H 4 acetylation levels and ratios of variants of histones H 3 and H2A that are like those in the dominant parent cell type , indicate that the control mechanisms affecting H 1 and H2B expression in H greater than M and in M greater than H hybrid cells affect expression of histones H2A , H 3 , and H 4 genes as well . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Using two dimensional electrophoresis , differential staining of electrophoregrams and ion exchange chromatography on CM cellulose the total preparation has been found to be made up of five fractions : two arginine rich ( one of them identical to histone H 4 , the other being similar to histone H 3 from calf thymus ) ; two moderately lysine rich fractions , slightly differing in their properties from histones H2A and H2B from calf thymus , and one specific fraction with mol . weight of 16 000 and an extremely high positive charge . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The results of these studies indicate that poly ( A ( ) ) 4 to 18 S RNA from S phase HeLa polyribosomes contains : ( a ) large quantities of discrete 7 . 4 and 8 S RNA species which are not functional histone mRNA ; ( b ) a discrete 8 . 6 S RNA fraction which contains the templates of human histone H 4 ; ( c ) 9 . 2 to 10 . 7 S RNA which contains mixtures of incompletely resolved histone H2B , H2A , and H 3 mRNA ( These mRNA species do not closely correspond to discrete RNA subfractions resolvable by our techniques . ) ; ( d ) discrete 12 and 13 S RNA fractions which contain templates of human histone H 1 polypeptides . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Since the conservatism of the core histones ( H2A , H2B , H 3 , and H 4 ) is clearly illustrated by comparative sequence analyses , the data shown here demonstrates that T . cruzi histone H 4 is the most divergent reported . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| A cytoplasmic histone acetyltransferase B , specific for histone H 4 , and two nuclear acetyltransferases A 1 and A 2 were identified ; A 1 acetylates all core histones with a preference for H 3 and H2A , whereas A 2 is specific for H 3 and also slightly for H2B . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Protein kinase p 62 phosphorylates enolase , tubulin and calpactin 1 as well as model substrates in the series : histone H 5 greater than poly ( G , T ) n greater than or equal to histone H2A greater than poly ( G , A , T ) n , histone H 4 greater than caseins , histones H 1 and H2B , poly ( G , A , L , T ) n . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| This effect is specific to histone H 4 in that large deletions in the N termini of H2A , H2B , and H 3 do not similarly decrease induction . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The purified protamine kinase exhibited about 5 % activity with casein , 8 % with histone H2B , and less than 0 . 1 % with histone H 1 , histone H 4 , glycogen synthase a from rabbit skeletal muscle , ovalbumin , bovine serum albumin , and phosvitin . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Histone H 4 and H2B genes in rainbow trout ( Salmo gairdnerii ) . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| From a computer aided search for homologies to know protein structures , it was found that the VegA protein has homologies to histone H 4 of Tetrahymena thermophila and histone H2B of sea urchin . . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| By contrast to histone H 4 , the overall levels of acetylation and the proportions of the different acetylated species of H2A , H2B and H 3 remain unchanged throughout the period examined . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| An acid urea polyacrylamide gel with a transverse Triton 10 100 gradient resolved and identified in a single gel at least one type of histone H 4 , two variant forms of histone H2B , two variant forms of histone H 3 , and four variant forms of histone H2A from a crude histone preparation . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Chicken histone H 4 , labeled at methionine 84 with 1 N pyrenyliodoacetamide , has been incorporated into a nucleosome like particle with core length DNA and unmodified histones H2A , H2B , and H 3 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Chicken histone H 4 , labeled separately at Met 84 with N [ [ ( iodoacetyl ) amino ] ethyl ] 5 naphthylamine 1 sulfonic acid and 5 ( iodoacetamido ) fluorescein , was reassociated with unlabeled histones H2A , H2B , and H 3 and 146 base pairs of DNA to produce fluorescently labeled nucleosomes having physical characteristics virtually the same as those of native core particles . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| When assayed with yeast whole histones , enzyme B shows a marked specificity toward histone H 4 , although H 3 and H2B are also accepted as substrates . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Four species of histone H 4 and three of histone H 3 occur with no alteration in histones H2A or H2B . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| In oocytes and embryos up to the tailbud stage , four types of mRNAs complementary to histone H2B DNA and two complementary to histone H 4 DNA can be discriminated by their different electrophoretic mobilities on polyacrylamide gels . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The core histones from Physarum , histones H2A , H2B , H 3 , and H 4 , are rapidly acetylated ; histone H 4 shows five subfractions , analogous to the five subfractions of mammalian histone H 4 ( containing zero to four acetyllysine residues per molecule ) ; histone H 3 has a more complex pattern that we interpret as zero to four acetyllysine residues on each of two sequence variants of histone H 3 ; histones H2A and H2B show less heterogeneity . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| On the basis of the reconstitution of a hybrid nucleosome containing calf histones H2A , H2B , and H 3 and yeast histone H 4 , it was concluded that variations in the yeast H 4 sequence are unlikely to be responsible for the apparent decrease in the stability of yeast nucleosomes . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequence of human spleen histone H 4 was investigated as part of a study on histone evolution , following previous investigations of human spleen histones H2B ( J . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| In accordance with the strength of their interaction with histone H 4 , the individual histone fractions can be arranged in the following order : H 4 greater than H2a greater than H2b greater than H 1 and protamine . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Two dimensional polyacrylamide electrophoresis and radiolabeling in butyrate treated cultures indicate the presence of at least one site of internal acetylation in histone H2A , four sites of internal acetylation in histone H2B , five sites of internal acetylation in histone H 3 , and four sites of internal acetylation in histone H 4 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Additionally , the gel reveals two protein bands , one ahead of histone H2B and another ahead of histone H 4 , that are diminished or missing from the inactive chromatin . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Cell density induced growth inhibition of osteosarcoma cells ( ROS 17 / 2 . 8 ) results in the shutdown of proliferation specific histone H 4 and H2B genes and the concomitant up regulation of several osteoblast related genes . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| This solitary arrangement of the two neighbouring histone H 4 and H2B genes is in contrast to the organization of ' cleavage stage ' histone genes , which are arranged in tandem quintets of genes encoding the 5 histone classes . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| There are three histone H 3 genes , two of which are identical ; four histone H2a genes , two of which are identical , one histone H 4 gene ; and two histone H2b genes . ^^^ These histone H 3 and H2a genes encode approximately 40 % of the total H 3 and H2a mRNA , whereas the histone H 4 and histone H2b genes encode < 10 % of the total H 4 and H2b mRNA . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The 42 sequenced genes encode six H 1 variants , three H2A variants , four H2B variants , two H 3 variants , and one histone H 4 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Here we report the analyses with a two hybrid system of the mutually interacting regions between hTAF ( 2 ) 80 and hTAF ( 2 ) 22 , which resemble histone H 4 and H2B , respectively . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| We recently reported the occurrence of a novel histone modification , involving a epsilon ( gamma glutamyl ) lysine cross link between a glutamine residue of histone H2B and a lysine residue of histone H 4 in the testis of the starfish , Asterina pectinifera [ Shimizu , T . , Hozumi , K . , Horiike , S . , Nunomura , K . , Ikegami , S . , Takao , T . , and Shimonishi , Y . ( 1996 ) Nature 380 , 32 ] . ^^^ Amino acid and positive ion FAB MS / MS analyses of K 10 showed that it to be a fragment , derived from Gly 8 Lys10 of histone H2B and Gly 9 Lys16 of histone H 4 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| We have determined the core histone residues acetylated in vitro by recombinant p 300 and PCAF within mononucleosomes . p 300 specifically acetylates all sites of histones H2A and H2B known to be acetylated in bulk chromatin in vivo but preferentially acetylates lysines 14 and 18 of histone H 3 and lysines 5 and 8 of histone H 4 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The Leishmania H2B and the amino terminal region of the histone H 4 , expressed as fusion proteins , when confronted with sera from canine viscerocutaneous leishmaniasis ( VCL ) dogs , were recognized by 63 % and 47 % , respectively . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate , using a combination of mass spectrometry , tandem mass spectrometry , and proteolytic digestion , that recombinant HOS 3 has a distinct specificity in vitro for histone H 4 sites K 5 and K 8 , H 3 sites K 14 and K 23 , H2A site K 7 , and H2B site K 11 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The in vitro immunoprecipitation experiment established that chp 46 interacts with histones H2B and H 4 and chicken histone acetyltransferase 1 , chHAT 1 , whereas hup 46 interacts with histones H2A and H 4 and chHAT 1 and chCAF 1p48 with histone H 4 and chHAT 1 . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| On average , acetylation half lives were approximately 15 min for histone H 4 , 10 min for histone H 3 , 4 min for histone H2B , and 5 min for histone H2A . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| In addition to the previously identified pair of genes that encode histones H 3 and H 4 ( hH 3 and hH 4 1 ) , we identified a second histone H 4 gene ( hH 4 2 ) , a divergently transcribed pair of genes that encode H2A and H2B ( hH2A and hH2B ) , a homolog of the F / Z family of H2A variants ( hH2Az ) , a homolog of the H 3 variant CSE 4 from Saccharomyces cerevisiae ( hH3v ) , and a highly diverged H 4 variant ( hH4v ) not described in other species . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Anti histone H 4 antibodies ( but not H2A , H2B , or H 3 antibodies ) quantitatively immunoadsorbed type 2 binding sites from nuclear extracts . ^^^ Binding analyses by [ 3H ] estradiol exchange , using luteolin as a competitor , detected specific type 2 binding activity to histone H 4 ( but not histones H2A , H2B , or H 3 ) generated in a rabbit reticulocyte lysate translation system and confirmed that histone H 4 is the type 2 site . . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The results obtained in this study indicate a statistically significant correlation between mRNA B 1 and mRNA H 4 ( p < 0 . 01 ) , B 2 and histone H 4 ( p < 0 . 01 ) B 1 and histone H2B ( p < 0 . 01 ) . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| In contrast , sequences at the N terminus appear to be critical for activation of histone H 4 and H2B reporter constructs . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The histone H2A , H2B , and H 3 genes and a partial sequence of the histone H 4 gene from Plasmodium falciparum have been previously identified and share a high level of nucleotide sequence identity . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Histone variants such as histone H3 . 3 , H2AX , and macroH2A appear to play key roles in the various stages of spermiogenesis , in addition to the specifically modulated acetylation of histone H 4 ( acH 4 ) , ubiquitination of histones H2A and H2B ( uH2A , uH2B ) , and phosphorylation of histone H 3 ( H3p ) . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| A histone heterodimer , designated as p 28 , which contains an Nepsilon ( gamma glutamyl ) lysine cross link between Gln 9 of histone H2B and Lys 5 or Lys 12 of histone H 4 , is present in starfish ( Asterina pectinifera ) sperm . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| The human histone H2A , H2B , and H 3 genes were expressed well in Escherichia coli cells , but the human histone H 4 gene was poorly expressed . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Histone H 3 showed at least seven sites of acetylation , histone H2B . 1 had six sites and histone H 4 had five sites . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| Besides the previously reported low H2A . 1 / H2A . 2 ratio [ Blankstein and Levy : Nature 260 : 638 640 , 1976 ] , chromatin from the most tumorigenic cell type showed the lowest H2B . 2 to H2B . 1 ratio , highest levels of histone H 4 acetylation , and the most pronounced change in relative amounts of two major electrophoretic bands of histone H 1 variants as compared to the less malignant cell types . ^^^ |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16778 and P62805 |
Pubmed |
SVM Score :0.0 |
| NA |
|