Using the pathway visualization tool GenMAPP , we found that several genes , including TbR 1 , STAT 1 , Smad 1 , Smad 2 , Jun , NFkappaB , and so on , in the TGF beta signaling pathway and p 115 RhoGEF , RhoGDI 3 , MEKK4A / MEKK4B , PI3KA , and JNK in the G 13 signaling pathway were differentially expressed in the tumors . ^^^