| Interacting proteins: Q15796 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Thus , CBP / p300 are important components of activin / TGF beta signaling and may mediate the antioncogenic functions of Smad 2 and Smad4 . . ^^^ |
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| Interacting proteins: Q15796 and Q92793 |
Pubmed |
SVM Score :0.0 |
| We demonstrate by both a mammalian two hybrid and a biochemical approach that human Smad 2 and Smad 4 , two essential Smad proteins involved in mediating TGF beta transcriptional responses in endothelial and other cell types , can functionally interact with the transcriptional coactivator CREB binding protein ( CBP ) . ^^^ Furthermore , Smad 2 , 4 CBP interactions involve the COOH terminus of CBP , a region that interacts with other regulated transcription factors such as certain signal transduction and transcription proteins and nuclear receptors . ^^^ |
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| Interacting proteins: Q15796 and Q92793 |
Pubmed |
SVM Score :0.0 |
| TGFbeta treatment of MEPM cells increased the levels of phosphorylated Smad 2 , phosphorylated cAMP response element binding protein ( CREB ) , and the coactivator , CREB binding protein ( CBP ) , that were part of a complex bound to the SBE . ^^^ Treatment of cells with forskolin , a stimulator of adenylate cyclase , increased the amount of phosphorylated CREB and CBP , but not the amount of phosphorylated Smad 2 bound in a complex to the SBE . ^^^ These results demonstrate that phosphorylated CREB forms a complex with the co activator CBP , phosphorylated Smad 2 and the co repressors c Ski and SnoN on a consensus SBE . ^^^ |
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| Interacting proteins: Q15796 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|