| Interacting proteins: Q13950 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Smad 2 overexpression enhances Smad 4 gene expression and suppresses CBFA 1 gene expression in osteoblastic osteosarcoma ROS17 / 2 . 8 cells and primary rat calvaria cells . ^^^ Since core binding factor A 1 ( CBFA 1 ) is involved in osteocalcin gene expression , we further examined CBFA 1 expression in the Smad 2 overexpressing ROS17 / 2 . 8 and PRC cells . ^^^ The levels of CBFA 1 mRNA were suppressed by the overexpression of Smad 2 by about 50 % in both ROS17 / 2 . 8 and PRC cells . ^^^ These data indicate that Smad 2 regulates Smad 4 specifically and that CBFA 1 gene is one of the downstream targets of Smad2 . . ^^^ |
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| Interacting proteins: Q13950 and Q15796 |
Pubmed |
SVM Score :0.0 |
| CBFA 1 could interact with Smad 1 , Smad 2 , Smad 3 , and Smad 5 , so it was involved in TGF beta and BMP 2 signal transduction , and played an important role in the bone formation . ^^^ |
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| Interacting proteins: Q13950 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta 1 regulation of collagenase 3 expression in osteoblastic cells by cross talk between the Smad and MAPK signaling pathways and their components , Smad 2 and Runx 2 . ^^^ Cotransfection of Smad 2 and Runx 2 constructs had a cooperative effect on TGF beta 1 stimulated collagenase 3 promoter activity in these cells . ^^^ We further identified ligand independent physical interaction between Smad 2 and Runx 2 . ^^^ |
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| Interacting proteins: Q13950 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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