Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P49790 and Q15796 Pubmed SVM Score :0.0
Smad 2 nucleocytoplasmic shuttling by nucleoporins CAN / Nup214 and Nup 153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus . ^^^ We uncovered direct interactions of Smad 2 with the nucleoporins CAN / Nup214 and Nup 153 . ^^^ CAN / Nup214 and Nup 153 compete with the cytoplasmic retention factor SARA and the nuclear Smad 2 partner FAST 1 for binding to a hydrophobic corridor on the MH 2 surface of Smad 2 . ^^^ TGFbeta receptor mediated phosphorylation stimulates nuclear accumulation of Smad 2 by modifying its affinity for SARA and Smad 4 but not for CAN / Nup214 or Nup 153 . ^^^