| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Differential roles of JNK and Smad 2 signaling pathways in the inhibition of c Myc induced cell death by TGF beta . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Here , we show that activation of JNK cascade blocked the ability of Smad 2 to mediate TGF beta dependent activation of the FAST proteins . ^^^ These studies thus reveal a mechanism for suppression of Smad 2 signaling pathway by JNK cascade through transcriptional repression . . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| The c Jun N terminal kinase ( JNK ) pathway , another downstream target activated by TGF beta receptors , has also been suggested to inhibit TGF beta signaling through interaction of c Jun with Smad 2 and Smad 3 . ^^^ Thus , the formation of a c Jun / Ski complex maintains the repressed state of Smad 2 responsive genes in the absence of ligand and participates in negative feedback regulation of TGF beta signaling by the JNK cascade . . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta 1 activates interleukin 6 expression in prostate cancer cells through the synergistic collaboration of the Smad 2 , p 38 NF kappaB , JNK , and Ras signaling pathways . ^^^ Here , we show that TGF beta 1 activates interleukin ( IL ) 6 , which has been implicated in the malignant progression of prostate cancers , via multiple signaling pathways including Smad 2 , nuclear factor kappaB ( NF kappaB ) , JNK , and Ras . ^^^ Cotransfection assays demonstrated that TGF beta 1 stimulation of IL 6 results from the synergistic collaboration of the Smad 2 , p 38 NF kappaB , JNK c Jun AP 1 , or Ras Raf MEK 1 cascades . ^^^ Collectively , our data demonstrate that IL 6 expression is stimulated by tumor producing TGF beta 1 in human prostate cancer cells through multiple signaling pathways including Smad 2 , p 38 , JNK , and Ras , and enhanced expression of IL 6 could contribute to the oncogenic switch of TGF beta 1 role for prostate tumorigenesis , in part by counteracting its growth suppression function . . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Investigation into the downstream targets and mechanisms involved in ALK 7 induced apoptosis revealed that the TGF beta signaling intermediates , Smad 2 and 3 , were activated , as well as the MAPKs JNK and p 38 . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Using the pathway visualization tool GenMAPP , we found that several genes , including TbR 1 , STAT 1 , Smad 1 , Smad 2 , Jun , NFkappaB , and so on , in the TGF beta signaling pathway and p 115 RhoGEF , RhoGDI 3 , MEKK4A / MEKK4B , PI3KA , and JNK in the G 13 signaling pathway were differentially expressed in the tumors . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , however , whereas activation of Smad 2 was rapid and maximal after 15 min incubation , activation of MAP kinases was delayed with p 38 stimulation detected after 1 h exposure and activation of ERK and JNK after 3 h , suggesting indirect activation of MAP kinases by TGF ( beta ) . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Although linker phosphorylated Smad 2 remained in the cytoplasm of alpha smooth muscle actin immunoreactive mesenchymal cells adjacent to necrotic hepatocytes in centrilobular areas , linker phosphorylated Smad 3 accumulated in the nuclei . c Jun N terminal kinase ( JNK ) in the activated HSCs directly phosphorylated Smad2 / 3 at linker regions . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Effects on transforming growth factor beta 1 ( TGF beta 1 ) receptor binding were analyzed by flow cytometry and on TGF beta 1 signal transduction by immunoblot analyses for Smad 4 and 7 , translocation from cytosol to nucleus for Smad 2 and 3 as well as for phosphorylated and unphosphorylated forms of p 38 , c Jun NH 2 terminal kinase ( JNK ) and extracellular regulated protein kinase ( ERK ) . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| In the TGF beta signaling pathway , TAK 1 deletion leads to impaired NF kappaB and c Jun N terminal kinase ( JNK ) activation without impacting Smad 2 activation or TGF beta induced gene expression . ^^^ |
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| Interacting proteins: P45983 and Q15796 |
Pubmed |
SVM Score :0.0 |
| AT1A mediated activation of kidney JNK 1 and SMAD 2 in obstructive uropathy : preservation of kidney tissue mass using candesartan . ^^^ We used a rat model of chronic unilateral ureteric obstruction to study the effects of candesartan , an AT ( 1A ) receptor blocker , on tissue morphology and the activities of JNK 1 and SMAD 2 protein in the kidney . ^^^ Ureteric obstruction for 28 days leads to interstitial fibrosis , tubule atrophy , and marked activation of SMAD 2 and JNK 1 , without significant change in p 38 kinase or ERK . ^^^ Furthermore , treatment with candesartan diminished JNK 1 activity and downregulated SMAD 2 protein and activity in obstructed kidneys . ^^^ In conclusion , obstructed kidneys showed chronic tubulointerstitial injury , which was associated with JNK 1 and SMAD 2 activation . ^^^ |
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