| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :1.0296795 |
| Here we show that Smad 2 and Smad 3 interacted with the kinase deficient TGF beta type 1 receptor ( TbetaR ) 1 after it was phosphorylated by TbetaR 2 kinase . 1.0296795^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| We analyzed the mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , the TGF beta receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) , Smad 2 , Smad 3 , and Smad 4 . mRNA expression of IL 10 and CD 95 ( FAS / APO 1 ) were also studied . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| METHODS : Paraffin embedded tissue sections containing tumor and adjacent nonneoplastic parenchyma were analyzed by immunohistochemistry for the expression of TbetaR type 2 ( TbetaR 2 ) and Smad 2 , Smad 4 , Smad 6 , and Smad 7 . ^^^ In the remaining 22 % , TbetaR 2 was preserved but Smad 2 expression was lost . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| To learn about the role of TGF beta in vivo , phenotypes of targeted mutations of molecules within the TGF beta signalling pathway , TGF beta 1 , beta 2 , beta 3 , TGF beta receptor ( TbetaR 2 ) and the signalling molecules SMAD 2 , SMAD 3 and SMAD 4 , are discussed in this review . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| A number of these cell lines carry inactivating mutations of the TGF beta type 2 ( TbetaR 2 ) receptor , and fail to phosphorylate receptor associated Smads , Smad 2 and Smad 3 . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| After 5 Aza treatment , these cells expressed TbetaR 2 at both mRNA and protein levels , which corresponded to the restoration of sensitivity to TGF beta by an increase in P Smad 2 . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Several proteins , including transforming growth factor beta ( TGF beta ) receptor type 1 ( RI ) , TGF beta receptor type 2 ( RII ) , Smad 2 , Smad 3 , and Smad4 / DPC4 , have been identified in the transduction pathway of the tumor suppressor TGF beta . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| In conclusion , we show that : 1 ) TGF beta receptor Type 2 is predominantly located on basolateral membrane and receptor stimulation activates Smad pathway ; 2 ) TGF beta 1 down regulates IL 6 induced tyrosine phoshorylation of STAT 1 and STAT 3 and ICAM 1 expression ; and 3 ) Smad 2 is required for the down regulation of IL 6 signaling by TGF beta . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Thus , inhibition of endogenous Smad 3 and Smad 2 gene expression resulted in stimulation of embryonic lung branching similar to that caused by inhibition of TGF beta type 2 receptor expression and signaling ( J . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Co transfection into SW480 . 7 cells of Smad 4 together with a Ras phosphorylation resistant Smad 3 ( but not with wild type Smad 2 , Smad 3 , adenomatous polyposis coli ( APC ) , or TGF beta type 2 receptor ) restored the TGF beta antiproliferative response . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Furthermore , treatment with TGF beta induced phosphorylation of Smad 2 in each of the SCCs with the exception of the two cell lines that carry inactivating mutations of the TGF beta type 2 receptor . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| These genes were TGF beta type 1 receptor gene ( TGFBR 1 ) , TGF beta type 2 receptor gene ( TGFBR 2 ) , SMAD 2 gene ( SMAD 2 ) , SMAD 3 gene ( SMAD 3 ) , SMAD 4 gene ( SMAD 4 ) , and SMAD 7 gene ( SMAD 7 ) , all of which compose the TGF beta 1 signaling pathway . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| The expression of TGF beta type 2 receptor protein was decreased in two of seven cell lines , and the expression of both Smad 2 and Smad 3 proteins was decreased in only one cell line . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of TGF beta type 2 receptor , Smad 2 , Smad 3 , Smad 4 , Smad 6 and Smad 7 genes in colorectal cancer . ^^^ Then , all coding regions of the TGF beta type 2 receptor ( TRII ) and the genes for Smad 2 , Smad 3 , Smad 4 , Smad 6 , and Smad 7 were analyzed by PCR SSCP and direct sequencing . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| TGF beta 1 and VEGF were assayed by enzyme linked immunosorbent assay ( ELISA ) ; alpha 3 ( 4 ) collagen , TGF beta type 2 receptor and phospho Smad 2 were assayed by immunoblotting . ^^^ The expression of alpha 3 ( 4 ) collagen was influenced by the TGF beta system , but AngII did not increase the podocyte ' s production of TGF beta 1 ligand ; rather , it increased the expression of the TGF beta type 2 receptor and activated the TGF beta signalling system through Smad 2 . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Here we show that in isolated human NK cells , proinflammatory monokines antagonize antiinflammatory TGF beta signaling by downregulating the expression of the TGF beta type 2 receptor , and its signaling intermediates SMAD 2 and SMAD 3 . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated in T47D cells transfected to express the transforming growth factor beta receptor type 2 ( TGF betaRII ) that insulin like growth factor binding protein 3 ( IGFBP 3 ) could stimulate Smad 2 and Smad 3 phosphorylation , potentiate TGF beta 1 stimulated Smad phosphorylation , and cooperate with exogenous TGF beta 1 in cell growth inhibition ( Fanayan , S . , Firth , S . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| The aim of our study was to determine the presence of alterations in the main putative components of the TGF beta inhibitory signaling pathways ( p 15 , Smad 4 , Smad 2 , TGFbeta RII , CDC25A ) . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| We report results of an association study between BMD and nine candidate genes ( TGFB 1 , TGFBR 2 , SMAD 2 , SMAD 3 , SMAD 4 , IFNB 1 , IFNAR 1 , FOS and LRP 5 ) , as well as of a case control study of osteoporosis . ^^^ |
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| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for the phosphorylated form of Smad 2 indicated a general loss in TGF beta signaling in the lamina propria of bladders of male and female Tgfbr 2 ( / spko ) , mice , and yet pronounced alpha smooth muscle actin expression was noted in male Tgfbr 2 ( / spko ) , bladders , which is a marker for myofibroblasts . ^^^ |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|