Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: Q15796 and P36897 Pubmed SVM Score :1.2108673
Here we show that Smad 2 and Smad 3 interacted with the kinase deficient TGF beta type 1 receptor ( TbetaR ) 1 after it was phosphorylated by TbetaR 2 kinase . 1.2108673^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
The vertebrate members of the MAD related family , termed Smad 2 and Smad 3 , interact specifically with the TGF beta type 1 receptor and are phosphorylated on the last two serines of a conserved C terminal SSXS motif . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Smad 2 and Smad 3 form homo oligomers upon phosphorylation by the constitutively active TGF beta type 1 receptor , and this oligomerization does not require Smad 4 . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
The ECM production stimulation by TGF beta or CA TbetaR 1 was accelerated by the overexpression of Smad 2 , Smad 3 , and / or Smad 4 and inhibited by that of Smad 7 . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
The L 45 sequence of the TGF beta type 1 receptor ( TbetaR 1 ) specifies Smad 2 interaction , whereas the related L 45 sequence of the bone morphogenetic protein ( BMP ) type 1 receptor ( BMPR 1 ) specifies Smad 1 interactions . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
These findings indicate that genetic defects in Smad 2 are sufficient to confer the invasion promoting effect of TGF beta and reveal that TGF beta acts through Smad 2 to induce cellular invasion by a novel mechanism that is independent of Smad 2 phosphorylation by the activated TGF beta type 1 receptor . . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
On the other hand , infections with low level CA ALK 5 , which alone did not result in transdifferentiation , together with Smad 2 and Smad 4 , or with Smad 3 and Smad 4 led to transdifferentiation . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Activation of TGF beta receptor type 1 ( RI ) and RII by TGF beta induces nuclear translocation of Smad proteins including Smad 2 and Smad 4 that have been originally identified as tumour suppressor genes . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
The fact that the TGF beta 1 induced complex between TbetaR II / ActR IIB and TbetaR 1 stimulated endogenous Smad 2 phosphorylation , a TGF beta like response , is in agreement with the current model for receptor activation in which the type 1 receptor determines signal specificity . . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
For example , Smad 2 is phosphorylated by the TGF beta type 1 receptor upon ligand binding , forms a heteromer with Smad 4 , and then translocates into the nucleus where it activates transcription . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
In addition , the levels of ALK 5 ( TD ) expression sufficient to restore motility in the cells expressing T beta RII K277R were associated with an increase in phosphorylation of Akt and extracellular signal regulated kinase 1 / 2 but not Smad 2 . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Our findings indicate that the TGF beta 1 type 1 receptor ALK 5 is expressed by odontoblasts as well as the signal transduction proteins Smad 2 , Smad 3 , and Smad 4 . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Here we show that Ski can block TGF beta signaling by interfering with the phosphorylation of Smad 2 and Smad 3 by the activated TGF beta type 1 receptor . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
We analyzed the mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , the TGF beta receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) , Smad 2 , Smad 3 , and Smad 4 . mRNA expression of IL 10 and CD 95 ( FAS / APO 1 ) were also studied . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
No mutations of Smad 2 , 3 , 4 , 5 and TGF beta type 1 receptor ( TGF beta IR ) genes were detected in a series of the tumors we tested , although several mutations of Smad 2 and 4 were previously reported . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
TGF beta mediated activation of TGF beta type 1 receptor stimulates the phosphorylation of Smad 2 and Smad 3 and subsequent heteromeric complex formation with Smad 4 . ^^^ Moreover , Smad 2 and Smad 3 interacted with P / CAF upon TGF beta type 1 receptor activation in cultured mammalian cells . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Two receptor activated Smad proteins , Smad 2 and Smad 3 , are phosphorylated by the activated TGF beta type 1 receptor kinase , after which they partner with the common mediator , Smad 4 , and are translocated to the nucleus to where they participate in transcriptional complexes to control expression of target genes . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
TGF beta induces phosphorylation of Smad1 / 5 and Smad 2 in endothelial cells and these effects can be blocked upon selective inhibition of ALK 1 or ALK 5 expression , respectively . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
We detected Smad 7 , phosphorylated Smad 2 , TGF beta type 1 receptor ( TbetaRI ) , and TGF beta ( 1 ) proteins in postmyocardial infarct ( MI ) rat hearts . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
These genes were TGF beta type 1 receptor gene ( TGFBR 1 ) , TGF beta type 2 receptor gene ( TGFBR 2 ) , SMAD 2 gene ( SMAD 2 ) , SMAD 3 gene ( SMAD 3 ) , SMAD 4 gene ( SMAD 4 ) , and SMAD 7 gene ( SMAD 7 ) , all of which compose the TGF beta 1 signaling pathway . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
A representative compound , SB 203580 , inhibited in vivo Smad 2 phosphorylation by TbetaR 1 and affected TGFbeta dependent transcriptional activation . ^^^ Peptides mimicking the TbetaR 1 phosphorylation sites at the C terminus of Smad 2 also inhibited the autophosphorylation of TbetaR 1 and phosphorylation of Smad 2 by TbetaR 1 in vitro and in vivo , whereas a similar peptide from Smad 5 was without effect . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Upon activation , the TGF beta type 1 receptor phosphorylates Smad 2 and Smad 3 , which then form complexes with Smad 4 and accumulate in the nucleus to regulate transcription of a variety of genes that encode crucial determinants of cell fate , such as cell cycle components , differentiation factors and cell adhesion molecules . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
In quiescent HSCs , TGF beta signaling involves TGF beta type 1 receptor ( TbetaRI ) mediated phosphorylation of serine residues within the conserved SSXS motif at the C terminus of Smad 2 and Smad 3 . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
In conclusion , although GDF 9 binds to the BMP activated type 2 receptor , its downstream actions are mediated by the type 1 receptor , ALK 5 , and the Smad 2 and Smad 3 proteins . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Smad3D407E was not phosphorylated by the constitutively active form of the TGF beta type 1 receptor , and inhibited the phosphorylation of co expressed wild type Smad 2 and Smad 3 . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Based on these observations , we conclude that the Smad 2 dependent Alk 5 signaling pathway is dominant in palatal fusion driven by Tgf beta3 . . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
We demonstrate that this compound selectively and concentration dependently inhibits ALK 4 , ALK 5 , and ALK 7 dependent activation of downstream cytoplasmic signal transducers , Smad 2 and Smad 3 , and of TGF beta induced mitogen activated protein kinase pathway components but does not alter ALK 1 , ALK 2 , ALK 3 or ALK 6 induced Smad signaling . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
The aim of this study was to assess the relationship between the expression of TGF beta cascade components , including TGF beta receptor type 1 ( TGF beta RI ) and type 2 ( TGF beta RII ) , SMAD 2 , SMAD 3 , SMAD 4 , and clinicopathological features tumor grade , FIGO classification , and depth of myometrial invasion of type 1 ( endometrioid type ) ECs to give some insight into the role of TGF beta cascade components in endometrial tumorigenesis . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
NEDD 4 2 ( neural precursor cell expressed , developmentally down regulated 4 2 ) negatively regulates TGF beta ( transforming growth factor beta ) signalling by inducing ubiquitin mediated degradation of Smad 2 and TGF beta type 1 receptor . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Using the pathway visualization tool GenMAPP , we found that several genes , including TbR 1 , STAT 1 , Smad 1 , Smad 2 , Jun , NFkappaB , and so on , in the TGF beta signaling pathway and p 115 RhoGEF , RhoGDI 3 , MEKK4A / MEKK4B , PI3KA , and JNK in the G 13 signaling pathway were differentially expressed in the tumors . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
In contrast , ALK 5 inhibition effectively blocked Smad 2 phosphorylation . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
Upon TGF beta binding the TGF beta type 1 receptor phosphorylates Smad 2 and Smad 3 , which then complex with Smad 4 and translocate to the nucleus , with subsequent activation of target genes . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
In addition to interacting stably with the activated TGF beta type 1 receptor ( TbetaRI ) to prevent phosphorylation of the receptor regulated Smads ( Smad 2 and Smad 3 ) , Smad 7 also induces degradation of the activated TbetaRI through association with different E 3 ubiquitin ligases . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
We also found that NS5A protein co localized with TbetaR 1 in the cytoplasm of Huh 7 cells and inhibited TGF beta mediated nuclear translocation of Smad 2 . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
The global gene expression analysis also indicated that the transforming growth factor beta ( TGF beta ) / activin branch components inhibin BC , ACVR2A , ACVR 1 ( ALK 2 ) , TGFBR 1 ( ALK 5 ) , and SMAD 2 were found to be highly expressed in undifferentiated states of these five hESC lines and decreased upon differentiation . ^^^
Interacting proteins: Q15796 and P36897 Pubmed SVM Score :0.0
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