| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.73708209 |
| The SnoN oncoprotein was found to interact with Smad 2 and Smad 4 and to repress their abilities to activate transcription through recruitment of the transcriptional corepressor N CoR . 0.73708209^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.60079468 |
| We have previously reported that Ski and SnoN interact directly with Smad 2 , Smad 3 , and Smad 4 and repress their ability to activate TGF beta target genes through multiple mechanisms . 0.60079468^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :1.541387 |
| SnoN physically interacted with activated Smad 2 by forming transcriptionally inactive complex and overrode the profibrotic action of TGF beta 1 . 1.541387^^^ |
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| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.54495213 |
| In the nucleus , SnoN binds to Smad 2 , Smad 3 , and Smad 4 and represses their ability to activate transcription of TGF beta target genes through multiple mechanisms . 0.54495213^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Whereas physiologic concentrations of SnoN and Ski allow a feedback regulation of TGFbeta signaling , deregulation of SnoN or Ski expression leads to total inhibition of TGFbeta signaling and of the tumor suppressors Smad 2 and Smad 4 , which can explain the role of SnoN and Ski as oncogenes . . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Smad 2 and Smad 3 both associate with the c Ski and Sno oncoproteins to repress transcription of Smad target genes via recruitment of a nuclear corepressor complex . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| The SKI and SnoN protein family associate with and repress the activity of Smad 2 , Smad 3 , and Smad 4 , three members of the TGF fl signaling pathway . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| However , in contrast with Smurf 2 , NEDD 4 2 failed to induce ubiquitination of SnoN ( Ski related novel protein N ) , although NEDD 4 2 bound to SnoN via Smad 2 more strongly than Smurf 2 . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Treatment of AFP expressing hepatoma cells with transforming growth factor beta 1 ( TGF beta 1 ) induced SnoN transcription and Smad 2 activation , concomitant with AFP repression . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Interestingly , Smad 2 and Smad 3 play opposite roles in regulating snoN expression in both fibroblasts and epithelial cells . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Smad 3 / chondrocytes lacked compensatory increases in Smad 2 , Smad 4 , TGFRII , Sno , or Smurf 2 and had reduced expression of TGF beta 1 and TGFRI . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Overall , the expression of the Smad 2 and Smad 3 proteins was low in the glioma cell lines , the phosphorylation and nuclear translocation of Smad 2 and Smad 3 were impaired , and the TGFbeta receptor signal did not affect the expression of the SnoN , p 21 , p 15 , cyclin D 1 , and CDK 4 proteins . ^^^ |
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| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| TGF beta induces assembly of a Smad 2 Smurf2 ubiquitin ligase complex that targets SnoN for degradation . ^^^ TGF beta also induces the association of Smurf 2 with the transcriptional co repressor SnoN and we show that Smad 2 can function to mediate this interaction . ^^^ |
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| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| On TGF beta stimulation , Smad 3 and Smad 2 translocate into the nucleus and induce a rapid degradation of SnoN , allowing activation of TGF beta target genes . ^^^ We show that Smad 2 or Smad 3 induced degradation of SnoN requires the ubiquitin dependent proteasome and can be mediated by the anaphase promoting complex ( APC ) and the UbcH 5 family of ubiquitin conjugating enzymes . ^^^ Smad 3 and to a lesser extent , Smad 2 , interact with both the APC and SnoN , resulting in the recruitment of the APC to SnoN and subsequent ubiquitination of SnoN in a destruction box ( D box ) dependent manner . ^^^ |
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| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Among receptor regulated Smads , c Ski and SnoN bind more strongly to Smad 2 and Smad 3 than to Smad 1 . ^^^ Smurf 2 induces ubiquitin dependent degradation of SnoN , since it appears to be located close to SnoN through binding to the linker region of Smad 2 . ^^^ |
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| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that phosphorylated CREB forms a complex with the co activator CBP , phosphorylated Smad 2 and the co repressors c Ski and SnoN on a consensus SBE . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| Basal mRNA levels of TGF beta receptors 1 and 2 , downstream signaling components Smad 2 , 3 , 4 , 6 , 7 , and the transcriptional corepressors Ski and SnoN did not show a statistically significant difference between HOSE and CSOC , and can not explain their differential susceptibility to TGF beta induced cell cycle arrest . ^^^ |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P12757 |
Pubmed |
SVM Score :0.0 |
| NA |
|