| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :1.0541643 |
| Here we show that a nuclear oncoprotein , Ski , can interact directly with Smad 2 , Smad 3 , and Smad 4 on a TGFbeta responsive promoter element and repress their abilities to activate transcription through recruitment of the nuclear transcriptional corepressor N CoR and possibly its associated histone deacetylase complex . 1.0541643^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.86714052 |
| Ski acts as a co repressor with Smad 2 and Smad 3 to regulate the response to type beta transforming growth factor . 0.86714052^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.53826986 |
| Here we show that c Jun directly interacts with Ski to enhance the association of Ski with Smad 2 in the basal state . 0.53826986^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.78737423 |
| We have previously reported that Ski and SnoN interact directly with Smad 2 , Smad 3 , and Smad 4 and repress their ability to activate TGF beta target genes through multiple mechanisms . 0.78737423^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Among receptor regulated Smads , c Ski and SnoN bind more strongly to Smad 2 and Smad 3 than to Smad 1 . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic C184M Ski complex inhibited the nuclear translocation of Smad 2 . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| We identified c Ski as a Smad 2 interacting protein . c Ski is the cellular homologue of the 5 ski oncogene product and has been shown to repress transcription by recruiting histone deacetylase ( HDAC ) . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate that phosphorylated CREB forms a complex with the co activator CBP , phosphorylated Smad 2 and the co repressors c Ski and SnoN on a consensus SBE . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| By RT PCR , transfection assays and immunohistochemistry , we show that ( 1 ) both MUC 4 mRNA and apomucin expression are upregulated by TGF beta , ( 2 ) Smad 2 positively cooperates with Smad 4 to activate the promoter , ( 3 ) activation of Smad 4 by exogenous TGF beta induces Smad 4 binding to the promoter , ( 4 ) Smad 7 and c ski both inhibit activation by Smad 4 . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Whereas physiologic concentrations of SnoN and Ski allow a feedback regulation of TGFbeta signaling , deregulation of SnoN or Ski expression leads to total inhibition of TGFbeta signaling and of the tumor suppressors Smad 2 and Smad 4 , which can explain the role of SnoN and Ski as oncogenes . . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Smad 2 and Smad 3 both associate with the c Ski and Sno oncoproteins to repress transcription of Smad target genes via recruitment of a nuclear corepressor complex . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| Basal mRNA levels of TGF beta receptors 1 and 2 , downstream signaling components Smad 2 , 3 , 4 , 6 , 7 , and the transcriptional corepressors Ski and SnoN did not show a statistically significant difference between HOSE and CSOC , and can not explain their differential susceptibility to TGF beta induced cell cycle arrest . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| The oncoprotein Ski acts as an antagonist of transforming growth factor beta signaling by suppressing Smad 2 phosphorylation . ^^^ The transcriptional activity of Smad 2 Smad4 or Smad 3 Smad4 complexes can be limited by the corepressor Ski , which is believed to interact with Smad complexes on TGF beta responsive promoters and represses their ability to activate TGF beta target genes by assembling on DNA a repressor complex containing histone deacetylase . ^^^ Here we show that Ski can block TGF beta signaling by interfering with the phosphorylation of Smad 2 and Smad 3 by the activated TGF beta type 1 receptor . ^^^ Furthermore , we demonstrate that overexpression of Ski induces the assembly of Smad 2 Smad4 and Smad 3 Smad4 complexes independent of TGF beta signaling . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| The SKI and SnoN protein family associate with and repress the activity of Smad 2 , Smad 3 , and Smad 4 , three members of the TGF fl signaling pathway . ^^^ |
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| Interacting proteins: P12755 and Q15796 |
Pubmed |
SVM Score :0.0 |
| SKI is known to curtail the growth inhibitory activity of tumor growth factor beta through the formation of repressive transcriptional complexes with Smad 2 and Smad 3 at the p 21 ( Waf 1 ) promoter . ^^^ |
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