| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.51720624 |
| Here we show that c Jun directly interacts with Ski to enhance the association of Ski with Smad 2 in the basal state . 0.51720624^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Smad 2 , 3 , and 4 and AP 1 complex ( c fos and c Jun ) cellular localization were evaluated by immunostaining . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Instead , we found that conophylline increased the expression of c Jun , which had been earlier shown to interact with the corepressor TGIF to suppress the transcriptional activity dependent on Smad 2 . ^^^ In cells overexpressing c Jun , suppression of promoter activity induced by TGF beta and the enhancement of the association of the Smad 2 complex with TGIF were also observed . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Pioglitazone inhibited AP 1 reporter activity but not Smad binding elements reporter activity without affecting TGF beta 1 induced activation of mitogen activated protein kinases ( MAPKs ) or Smad 2 . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Using the pathway visualization tool GenMAPP , we found that several genes , including TbR 1 , STAT 1 , Smad 1 , Smad 2 , Jun , NFkappaB , and so on , in the TGF beta signaling pathway and p 115 RhoGEF , RhoGDI 3 , MEKK4A / MEKK4B , PI3KA , and JNK in the G 13 signaling pathway were differentially expressed in the tumors . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Acceleration of Smad 2 and Smad 3 phosphorylation via c Jun NH ( 2 ) terminal kinase during human colorectal carcinogenesis . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Although linker phosphorylated Smad 2 remained in the cytoplasm of alpha smooth muscle actin immunoreactive mesenchymal cells adjacent to necrotic hepatocytes in centrilobular areas , linker phosphorylated Smad 3 accumulated in the nuclei . c Jun N terminal kinase ( JNK ) in the activated HSCs directly phosphorylated Smad2 / 3 at linker regions . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Effects on transforming growth factor beta 1 ( TGF beta 1 ) receptor binding were analyzed by flow cytometry and on TGF beta 1 signal transduction by immunoblot analyses for Smad 4 and 7 , translocation from cytosol to nucleus for Smad 2 and 3 as well as for phosphorylated and unphosphorylated forms of p 38 , c Jun NH 2 terminal kinase ( JNK ) and extracellular regulated protein kinase ( ERK ) . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| In addition , HIV 1 gp 120 results in phosphorylation of Smad 2 and decreases c Jun . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| In the TGF beta signaling pathway , TAK 1 deletion leads to impaired NF kappaB and c Jun N terminal kinase ( JNK ) activation without impacting Smad 2 activation or TGF beta induced gene expression . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Smad 2 , 3 , and 4 and AP 1 complex ( c fos and c Jun ) cellular localization were evaluated by immunostaining . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| Cotransfection assays demonstrated that TGF beta 1 stimulation of IL 6 results from the synergistic collaboration of the Smad 2 , p 38 NF kappaB , JNK c Jun AP 1 , or Ras Raf MEK 1 cascades . ^^^ |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15796 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|