| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.78423939 |
| Association of cPGES with Hsp 90 was increased in cells stimulated with A 23187 or bradykinin , accompanied by concomitant increases in cPGES activity and PGE ( 2 ) production . 0.78423939^^^ |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| Cytosolic PGES ( cPGES ) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 ( Hsp 90 ) . ^^^ |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| We find that the regulation of cPGES / p23 activity in cells depends on its association with hsp 90 . ^^^ |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| Cytosolic PGES ( cPGES ) is identical to the Hsp 90 chaperone , p 23 , and is reportedly functionally coupled to constitutive PG endoperoxide H synthase 1 ( PGHS 1 ) . ^^^ |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| In activated cells , cPGES phosphorylation occurred in parallel with increased cPGES enzymic activity and PGE 2 production from exogenous and endogenous arachidonic acid , and these processes were facilitated by Hsp 90 ( heat shock protein 90 ) , a molecular chaperone that formed a tertiary complex with cPGES and CK 2 . ^^^ Treatment of cells with inhibitors of CK 2 and Hsp 90 and with a dominant negative CK 2 attenuated the formation of the cPGES CK 2 Hsp 90 complex and attendant cPGES phosphorylation and activation . ^^^ Moreover , the CK 2 Hsp 90 mediated activation of cPGES was ameliorated by the p 38 mitogen activated protein kinase inhibitor SB 20358 or by the anti inflammatory glucocorticoid dexamethasone . ^^^ |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| In the present study the antigen of the clone 22 antibody was identified as the heat shock protein 90 ( HSP 90 ) co chaperone protein p 23 , identical to the cytosolic prostaglandin E 2 synthase , by immunoprecipitation followed by tryptic in gel digests and mass spectrometry of the purified peptides . ^^^ |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15185 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|