| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of Oligo 2 in vivo causes ectopic expression of Sox 10 , an HMG box transcription factor expressed in oligodendrocyte and other glial precursors . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| This stems from the recent identification of three new transcription factor genes , Olig 1 , Olig 2 and Sox 10 , that are expressed from the early stages of oligodendrocyte lineage development . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| They first appear within a region of anterior hypothalamic neuroepithelium that co expresses mRNA encoding SHH , its receptor PTC 1 ( PTCH ) and the transcription factors OLIG 1 , OLIG 2 and SOX 10 . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| Moreover , coexpression of Olig 2 with Nkx2 . 2 in the chick neural tube generated cells expressing Sox 10 , a marker of oligodendroglial precursors . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| Furthermore , a population of Olig 2 expressing NSFCs also expressed Sox 10 . ^^^ Cotransfection of NSFCs with Nkx2 . 2 and Sox 10 , but not Olig 2 and Sox 10 , produced a MBP ( + ) oligodendrocytic phenotype . ^^^ Coculture of NSFCs transfected with Olig 2 and Nkx2 . 2 or Nkx2 . 2 and Sox 10 with purified sensory neurons , demonstrated frequent contacts between NSFC processes and axons , including the early stages of ensheathment . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| This may be specific to SOX 10 , because the CpG island of OLIG 2 , which encodes another oligodendrocyte specific transcription factor , was rarely methylated in brains , and the methylation status of myelin associated oligodendrocytic basic protein , which encodes structural protein in oligodendrocytes , did not account for their expressions or other oligodendrocyte gene expressions . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| Recent studies suggest that specific neural basic helix loop helix ( HLH ; i . e . , Olig 1 and Olig 2 , Mash 1 ) , associated inhibitory HLH ( i . e . , Id 2 and Id 4 ) , high mobility group domain ( i . e . , Sox 10 ) , and homeodomain ( i . e . , Nkx2 . 2 ) transcription factors are involved in oligodendrocyte ( OL ) lineage specification and progressive stages of maturation including myelination . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| Commitment of ventral neural progenitors to the oligodendrocyte fate is thought to require co ordinate , hedgehog dependent expression of olig 2 and nkx2 . 2a in these cells , leading to expression of sox 10 and subsequent differentiation of oligodendrocytes . ^^^ Remarkably , transcription of olig 2 is extinguished in ventral neural progenitors of the hdac 1 mutant hindbrain , whereas expression of nkx2 . 2a is up regulated in these cells , and sox 10 expression is suppressed . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| Although activity of the transcription factors ( TFs ) Olig 1 , Olig 2 , Sox 10 , and Nkx2 . 2 is required during early oligodendrocyte development , their later expression in adult central nervous system is rather poorly characterized . ^^^ |
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| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13516 and P56693 |
Pubmed |
SVM Score :0.0 |
| NA |
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