| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.59825601 |
| We show here that the Olig 2 protein can form a physical complex with Nkx2 . 2 protein in mammalian cells and yeast two hybrid trap assay . 0.59825601^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Moreover , coexpression of Olig 2 with Nkx2 . 2 in the chick neural tube generated cells expressing Sox 10 , a marker of oligodendroglial precursors . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| The bHLH transcription factor Olig 2 promotes oligodendrocyte differentiation in collaboration with Nkx2 . 2 . ^^^ Just prior to oligo dendrocyte precursor formation , the domains of Olig 2 and Nkx2 . 2 expression switch from being mutually exclusive to overlapping , and Neurogenins 1 and 2 are extinguished within this region . ^^^ Coexpression of Olig 2 with Nkx2 . 2 in the spinal cord promotes ectopic and precocious oligodendrocyte differentiation . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Adult and embryonic progenitors commonly expressed various homeodomain type ( Pax 6 , Pax 7 , Nkx2 . 2 , and Prox 1 ) and basic helix loop helix ( bHLH ) type ( Ngn 2 , Mash 1 , NeuroD 1 , and Olig 2 ) transcriptional regulatory factors in vitro . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig 2 and Nkx2 . 2 in the control of oligodendrocyte differentiation . ^^^ In this study , we have investigated the relationship of Olig2+ and Nkx2 . 2+ oligodendrocyte progenitors ( OLPs ) by comparing the expression of Olig 2 and Nkx2 . 2 in embryonic chicken and mouse spinal cords before and during the stages of oligodendrogenesis . ^^^ At the stages of neurogenesis , Olig 2 and Nkx2 . 2 are expressed in adjacent non overlapping domains of ventral neuroepithelium . ^^^ Despite their distinct origins , both populations of OLPs eventually appear to co express Olig 2 and Nkx2 . 2 in the same cells . ^^^ The co expression of Nkx2 . 2 and Olig 2 in OLPs is tightly associated with myelin gene expression in the normal and PDGFA ( / ) embryos , suggesting a cooperative role of these transcription factors in the control of oligodendrocyte differentiation . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Strikingly , among the transcription factors involved in OLP specification , BMP treatment strongly inhibited the expression of Olig 2 but not of Nkx2 . 2 , suggesting that BMP mediated inhibition of oligodendrogenesis is controlled through the repression of the former transcription factor . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| In addition , Nkx2 . 2 and Olig 2 are co expressed in the same OLPs generated from the dorsal midbrain , suggesting that the dorsal oligodendrogenesis is similarly under the dual control of these two transcription factors as in the developing spinal cord . . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| We show that Nkx2 . 2 and Olig 2 , which are present initially in nonoverlapping domains , are coexpressed at later stages , likely due to a second wave of Olig expression . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| We investigated the mRNA expression of OLIG 1 and OLIG 2 , as well as four other genes involved in oligodendrocyte development ( E2A , HEB , NKX2 . 2 , and PDGFRA ) in a panel of 70 gliomas , including 9 oligodendrogliomas , 11 anaplastic oligodendrogliomas , 5 oligoastrocytomas , 10 anaplastic oligoastrocytomas , 10 diffuse astrocytomas , 10 anaplastic astrocytomas , and 15 glioblastomas . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| In particular , the transcription factors ( TFs ) Olig 2 , Pax 6 , and Nkx2 . 2 have been shown to be important in the specification and / or maturation of the OG lineage . ^^^ Serial transverse spinal cord sections from embryonic days 12 . 5 , 14 . 25 , 16 , and 18 Hoxa 2 ( + / + ) , Hoxa 2 ( + / ) , and Hoxa 2 ( / ) mice were subjected to single and double immunohistochemical analysis in order to examine Hoxa 2 , Olig 2 , Nkx2 . 2 , and Pax 6 expression profiles . ^^^ In addition , comparison of spinal cord sections obtained from Hoxa 2 ( + / + ) , Hoxa 2 ( + / ) , and Hoxa 2 ( / ) mice suggested that specification and early maturation of OGs proceeded normally in the absence of Hoxa 2 , since there were no obvious alterations in the expression patterns of Olig 2 , Nkx2 . 2 , and / or Pax 6 . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Increased expression of Nkx2 . 2 and Olig 2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS . ^^^ During development , OPC differentiation is controlled by several transcription factors including Olig 1 and Olig 2 , and Nkx2 . 2 . ^^^ During the acute phase of demyelination , OPCs within the lesion increased their expression of Nkx2 . 2 and Olig 2 , two transcription factors that in combination are critical for oligodendrocyte differentiation during developmental myelination . ^^^ Our data suggest the hypothesis that increased expression of Nkx2 . 2 and Olig 2 plays a critically important role in the differentiation of adult OPCs into remyelinating oligodendrocytes and that these genes may present novel targets for therapeutic manipulation in cases where remyelination is impaired . . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| At 7 dpi , a significant up regulation of Nkx2 . 2 by OPCs within the lesion was observed , 90 % of which coexpressed NG 2 and virtually all of which coexpressed the bHLH transcription factor Olig 2 . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Recent studies suggest that specific neural basic helix loop helix ( HLH ; i . e . , Olig 1 and Olig 2 , Mash 1 ) , associated inhibitory HLH ( i . e . , Id 2 and Id 4 ) , high mobility group domain ( i . e . , Sox 10 ) , and homeodomain ( i . e . , Nkx2 . 2 ) transcription factors are involved in oligodendrocyte ( OL ) lineage specification and progressive stages of maturation including myelination . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| In this study , we transfected NSCs isolated from the embryonic mouse brain with the Olig 2 gene and found that the introduced overexpression of Olig 2 could induce the development of fully mature oligodendrocytes expressing the transcription factor Nkx2 . 2 and all major myelin specific proteins . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Using markers ( Nkx2 . 2 , Nkx6 . 1 , Olig 2 , Pax 6 and Dbx 1 ) for one or multiple progenitor cell types , we found reductions of all subtypes of progenitor cells in the ventral spinal cord of Notch 1 cKO mice . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| The proteins Pax 6 , Emx 2 , Sox 2 , 3 and Olig 1 were predominantly localized to dividing neural precursors while the factors Sox 1 , Ngn 1 , Dlx 1 , 5 , Olig 2 and Nkx2 . 2 were mainly expressed by neuronal precursors . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| Although activity of the transcription factors ( TFs ) Olig 1 , Olig 2 , Sox 10 , and Nkx2 . 2 is required during early oligodendrocyte development , their later expression in adult central nervous system is rather poorly characterized . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| The transcription factors involved in MN specification ( Pax 6 , Nkx6 . 1 , and Olig 2 ) are all expressed in the CNT , despite the lower expression level of Pax 6 , but an overlap between Olig 2 and the ventrally expressed transcription factor Nkx2 . 2 is observed in the CNT . ^^^ |
|
| Interacting proteins: O95096 and Q13516 |
Pubmed |
SVM Score :0.0 |
| To evaluate the potential of NSFCs to form oligodendrocytes , two transcription factors , Olig 2 and Nkx2 . 2 , were introduced into NSFCs to determine whether their expression is sufficient for oligodendrocyte differentiation , as has been shown in the embryonic avian and murine central nervous systems in vivo . ^^^ NSFCs transfected with Olig 2 or Nkx2 . 2 alone exhibited no phenotypic lineage restriction . ^^^ In contrast , simultaneous transfection of Olig 2 and Nkx2 . 2 cDNA produced characteristic oligodendrocyte morphology and antigenicity , including myelin basic protein ( MBP ) . ^^^ Cotransfection of NSFCs with Nkx2 . 2 and Sox 10 , but not Olig 2 and Sox 10 , produced a MBP ( + ) oligodendrocytic phenotype . ^^^ Coculture of NSFCs transfected with Olig 2 and Nkx2 . 2 or Nkx2 . 2 and Sox 10 with purified sensory neurons , demonstrated frequent contacts between NSFC processes and axons , including the early stages of ensheathment . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.59825601 |
| We show here that the Olig 2 protein can form a physical complex with Nkx2 . 2 protein in mammalian cells and yeast two hybrid trap assay . 0.59825601^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Moreover , coexpression of Olig 2 with Nkx2 . 2 in the chick neural tube generated cells expressing Sox 10 , a marker of oligodendroglial precursors . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| The bHLH transcription factor Olig 2 promotes oligodendrocyte differentiation in collaboration with Nkx2 . 2 . ^^^ Just prior to oligo dendrocyte precursor formation , the domains of Olig 2 and Nkx2 . 2 expression switch from being mutually exclusive to overlapping , and Neurogenins 1 and 2 are extinguished within this region . ^^^ Coexpression of Olig 2 with Nkx2 . 2 in the spinal cord promotes ectopic and precocious oligodendrocyte differentiation . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Adult and embryonic progenitors commonly expressed various homeodomain type ( Pax 6 , Pax 7 , Nkx2 . 2 , and Prox 1 ) and basic helix loop helix ( bHLH ) type ( Ngn 2 , Mash 1 , NeuroD 1 , and Olig 2 ) transcriptional regulatory factors in vitro . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig 2 and Nkx2 . 2 in the control of oligodendrocyte differentiation . ^^^ In this study , we have investigated the relationship of Olig2+ and Nkx2 . 2+ oligodendrocyte progenitors ( OLPs ) by comparing the expression of Olig 2 and Nkx2 . 2 in embryonic chicken and mouse spinal cords before and during the stages of oligodendrogenesis . ^^^ At the stages of neurogenesis , Olig 2 and Nkx2 . 2 are expressed in adjacent non overlapping domains of ventral neuroepithelium . ^^^ Despite their distinct origins , both populations of OLPs eventually appear to co express Olig 2 and Nkx2 . 2 in the same cells . ^^^ The co expression of Nkx2 . 2 and Olig 2 in OLPs is tightly associated with myelin gene expression in the normal and PDGFA ( / ) embryos , suggesting a cooperative role of these transcription factors in the control of oligodendrocyte differentiation . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Strikingly , among the transcription factors involved in OLP specification , BMP treatment strongly inhibited the expression of Olig 2 but not of Nkx2 . 2 , suggesting that BMP mediated inhibition of oligodendrogenesis is controlled through the repression of the former transcription factor . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| In addition , Nkx2 . 2 and Olig 2 are co expressed in the same OLPs generated from the dorsal midbrain , suggesting that the dorsal oligodendrogenesis is similarly under the dual control of these two transcription factors as in the developing spinal cord . . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| We show that Nkx2 . 2 and Olig 2 , which are present initially in nonoverlapping domains , are coexpressed at later stages , likely due to a second wave of Olig expression . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| We investigated the mRNA expression of OLIG 1 and OLIG 2 , as well as four other genes involved in oligodendrocyte development ( E2A , HEB , NKX2 . 2 , and PDGFRA ) in a panel of 70 gliomas , including 9 oligodendrogliomas , 11 anaplastic oligodendrogliomas , 5 oligoastrocytomas , 10 anaplastic oligoastrocytomas , 10 diffuse astrocytomas , 10 anaplastic astrocytomas , and 15 glioblastomas . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| The transcription factors involved in MN specification ( Pax 6 , Nkx6 . 1 , and Olig 2 ) are all expressed in the CNT , despite the lower expression level of Pax 6 , but an overlap between Olig 2 and the ventrally expressed transcription factor Nkx2 . 2 is observed in the CNT . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| To evaluate the potential of NSFCs to form oligodendrocytes , two transcription factors , Olig 2 and Nkx2 . 2 , were introduced into NSFCs to determine whether their expression is sufficient for oligodendrocyte differentiation , as has been shown in the embryonic avian and murine central nervous systems in vivo . ^^^ NSFCs transfected with Olig 2 or Nkx2 . 2 alone exhibited no phenotypic lineage restriction . ^^^ In contrast , simultaneous transfection of Olig 2 and Nkx2 . 2 cDNA produced characteristic oligodendrocyte morphology and antigenicity , including myelin basic protein ( MBP ) . ^^^ Cotransfection of NSFCs with Nkx2 . 2 and Sox 10 , but not Olig 2 and Sox 10 , produced a MBP ( + ) oligodendrocytic phenotype . ^^^ Coculture of NSFCs transfected with Olig 2 and Nkx2 . 2 or Nkx2 . 2 and Sox 10 with purified sensory neurons , demonstrated frequent contacts between NSFC processes and axons , including the early stages of ensheathment . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| In particular , the transcription factors ( TFs ) Olig 2 , Pax 6 , and Nkx2 . 2 have been shown to be important in the specification and / or maturation of the OG lineage . ^^^ Serial transverse spinal cord sections from embryonic days 12 . 5 , 14 . 25 , 16 , and 18 Hoxa 2 ( + / + ) , Hoxa 2 ( + / ) , and Hoxa 2 ( / ) mice were subjected to single and double immunohistochemical analysis in order to examine Hoxa 2 , Olig 2 , Nkx2 . 2 , and Pax 6 expression profiles . ^^^ In addition , comparison of spinal cord sections obtained from Hoxa 2 ( + / + ) , Hoxa 2 ( + / ) , and Hoxa 2 ( / ) mice suggested that specification and early maturation of OGs proceeded normally in the absence of Hoxa 2 , since there were no obvious alterations in the expression patterns of Olig 2 , Nkx2 . 2 , and / or Pax 6 . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Increased expression of Nkx2 . 2 and Olig 2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS . ^^^ During development , OPC differentiation is controlled by several transcription factors including Olig 1 and Olig 2 , and Nkx2 . 2 . ^^^ During the acute phase of demyelination , OPCs within the lesion increased their expression of Nkx2 . 2 and Olig 2 , two transcription factors that in combination are critical for oligodendrocyte differentiation during developmental myelination . ^^^ Our data suggest the hypothesis that increased expression of Nkx2 . 2 and Olig 2 plays a critically important role in the differentiation of adult OPCs into remyelinating oligodendrocytes and that these genes may present novel targets for therapeutic manipulation in cases where remyelination is impaired . . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| At 7 dpi , a significant up regulation of Nkx2 . 2 by OPCs within the lesion was observed , 90 % of which coexpressed NG 2 and virtually all of which coexpressed the bHLH transcription factor Olig 2 . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Recent studies suggest that specific neural basic helix loop helix ( HLH ; i . e . , Olig 1 and Olig 2 , Mash 1 ) , associated inhibitory HLH ( i . e . , Id 2 and Id 4 ) , high mobility group domain ( i . e . , Sox 10 ) , and homeodomain ( i . e . , Nkx2 . 2 ) transcription factors are involved in oligodendrocyte ( OL ) lineage specification and progressive stages of maturation including myelination . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| In this study , we transfected NSCs isolated from the embryonic mouse brain with the Olig 2 gene and found that the introduced overexpression of Olig 2 could induce the development of fully mature oligodendrocytes expressing the transcription factor Nkx2 . 2 and all major myelin specific proteins . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Using markers ( Nkx2 . 2 , Nkx6 . 1 , Olig 2 , Pax 6 and Dbx 1 ) for one or multiple progenitor cell types , we found reductions of all subtypes of progenitor cells in the ventral spinal cord of Notch 1 cKO mice . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| The proteins Pax 6 , Emx 2 , Sox 2 , 3 and Olig 1 were predominantly localized to dividing neural precursors while the factors Sox 1 , Ngn 1 , Dlx 1 , 5 , Olig 2 and Nkx2 . 2 were mainly expressed by neuronal precursors . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| Although activity of the transcription factors ( TFs ) Olig 1 , Olig 2 , Sox 10 , and Nkx2 . 2 is required during early oligodendrocyte development , their later expression in adult central nervous system is rather poorly characterized . ^^^ |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13516 and O95096 |
Pubmed |
SVM Score :0.0 |
| NA |
|