| Interacting proteins: Q02078 and Q9UQL6 |
Pubmed |
SVM Score :0.0 |
| We found that HDAC 5 was able to interact in vivo and in vitro with MEF2A , a MADS box transcription factor , and to strongly inhibit its transcriptional activity . ^^^ The N terminal non deacetylase domain of HDAC 5 was able to ensure an efficient repression of MEF2A dependent transcription . ^^^ We then mapped protein domains involved in the HDAC 5 MEF2A interaction and showed that MADS box / MEF2 domain region of MEF2A interacts specifically with a limited region in the N terminal part of HDAC 5 which also possesses a distinct repressor domain . ^^^ |
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| Interacting proteins: Q02078 and Q9UQL6 |
Pubmed |
SVM Score :0.0 |
| Here a combination of proteolytic fragmentation , matrix assisted laser desorption ionization mass spectrometry , Edman degradation , circular dichroism , gel filtration , and surface plasmon resonance studies is utilized to define and characterize a stable core domain of HDAC 5 and to examine its interactions with MEF2a and calmodulin . ^^^ Results from real time binding experiments provide evidence for direct interaction of Ca ( 2+ ) / calmodulin with HDAC 5 inhibiting MEF2a association with this enzyme . . ^^^ |
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| Interacting proteins: Q02078 and Q9UQL6 |
Pubmed |
SVM Score :0.0 |
| Consequently , we show that ICP 0 is able to overcome the HDAC 5 amino terminal and MITR induced MEF2A repression in gene reporter assays . ^^^ |
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| Interacting proteins: Q02078 and Q9UQL6 |
Pubmed |
SVM Score :0.0 |
| NA |
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