| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| To identify new CT antigens , we constructed an expression cDNA library from a melanoma cell line that expresses a wide range of CT antigens and screened the library with an allogeneic melanoma patient serum known to contain antibodies against two CT antigens , MAGE 1 and NY ESO 1 . cDNA clones isolated from this library identified four CT antigen genes : MAGE 4a , NY ESO 1 , LAGE 1 , and CT 7 . ^^^ LAGE 1 is a member of the NY ESO 1 gene family , and CT 7 is a newly defined gene with partial sequence homology to the MAGE family at its carboxyl terminus . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| Monophasic and biphasic synovial sarcomas abundantly express cancer / testis antigen NY ESO 1 but not MAGE A 1 or CT 7 . ^^^ The present study was performed to analyze the expression of 3 CT antigens , NY ESO 1 , MAGE A 1 and CT 7 , by immunohistochemistry with 3 monoclonal antibodies ( MAbs ) , ES 121 ( anti NY ESO 1 ) , MA 454 ( anti MAGE A 1 ) and CT 7 33 ( anti CT 7 ) , in 25 synovial sarcomas ( 12 MSS , 13 BSS ) typed for the t ( 10 ; 18 ) derived fusion transcript by RT PCR ( 19 SYT SSX 1 , 6 SYT SSX 2 ) . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| In the present study , 54 sarcoma patients were tested for serum antibodies to NY ESO 1 , SSX 2 , MAGE A 1 , MAGE A 3 , MAGE A 4 , MAGE A 10 , CT 7 , and CT 10 . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| Expression of cancer / testis ( CT ) antigens MAGE A 1 , MAGE A 3 , MAGE A 4 , CT 7 , and NY ESO 1 in malignant gammopathies is heterogeneous and correlates with site , stage and risk status of disease . ^^^ We examined the expression of a panel of CT antigenic proteins in 29 patients with malignant gammopathies by immunohistochemistry using the following monoclonal antibodies ( mAbs ) : mAb MA 454 to MAGE A 1 , mAb M3H67 to MAGE A 3 , mAb 57B to MAGE A 4 , mAb CT 7 33 to CT7 / MAGE C 1 and mAb ES 121 to NY ESO 1 . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| The following anti CT monoclonal antibodies / antigens were studied by immunohistochemistry : monoclonal antibody ES121 / NY ESO 1 , monoclonal antibody M3H67 / MAGE A 3 , monoclonal antibody 57B / MAGE A 4 , and monoclonal antibody CT 7 33 / CT7 . ^^^ CT antigens CT 7 , MAGE A 3 and MAGE A 4 , but not NY ESO 1 , are expressed in high grade endometrial carcinomas , and expression of MAGE A 4 is correlated with the presence of overexpressed p53 . . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| In 98 evaluable cases , SCP 1 and SSX 4 were expressed most frequently ( both 65 % ) , followed by HOM TES 85 / CT 8 ( 47 % ) , GAGE ( 26 % ) , SSX 1 ( 20 % ) , NY ESO 1 ( 13 % ) , MAGE 3 ( 11 % ) , SSX 2 ( 8 % ) , CT 10 ( 7 % ) , MAGE 4 ( 4 % ) and CT 7 ( 1 % ) . ^^^ Of 100 serum samples screened for CT antigen specific antibodies , antibodies against NY ESO 1 were detected in 4 patients , against SCP 1 in 6 patients and against SSX 2 in 1 patient , while no antibodies were detected against MAGE 3 , CT 7 and CT 10 . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated the IgG antibody response against 11 cancer testis antigens ( SCP 1 , GAGE , LAGE 1a , 1b , CT 7 , NY ESO 1 , SSX 1 5 ) recombinantly expressed on yeast surface ( RAYS ) in patients with pancreatic cancer ( n = 96 ) , chronic pancreatitis ( n = 18 ) and healthy donors ( n = 48 ) . ^^^ We found in 14 % of all patients antibody responses to SCP 1 , but not to other cancer testis antigens ( GAGE , LAGE 1a , 1b , CT 7 , NY ESO 1 , SSX 1 5 ) . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| From a panel of eleven CTA ( MAGE 1 , MAGE C 1 , MAGE 3 , BAGE , GAGE , SSX 1 , SSX 2 , SSX 4 , SCP 1 , NY ESO 1 and TS 85 ) ( HOM Tes 85 ) , mRNA expression could be detected for SCP 1 in 8 / 17 MF and 6 / 8 pleomorphic CTCL patients but was completely absent in small plaques parapsoriasis . ^^^ SS patients had a more heterogeneous antigen expression pattern : Gage ( 1 / 11 ) , MAGE 1 ( 3 / 11 ) , MAGE 3 ( 6 / 11 ) , MAGE C 1 ( 5 / 11 ) , NY ESO 1 ( 7 / 11 ) and TS 85 ( 5 / 11 ) , with expression of MAGE 3 confirmed by immunohistochemistry . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression frequencies of CT antigens in tumor tissue were : MAGE A 1 , 69 . 9 % ; MAGE A 3 , 47 . 9 % ; MAGE A 4 , 20 . 0 % ; MAGE A 10 , 36 . 7 % ; SSX 1 , 67 . 4 % ; SSX 2 , 35 . 6 % ; SSX 4 , 48 . 8 % ; SSX 5 , 30 . 2 % ; NY ESO 1 , 42 . 5 % ; MAGE B 1 , 52 . 0 % ; MAGE B 2 , 60 . 0 % ; MAGE C 1 , 48 . 0 % ; MAGE C 2 , 68 . 0 % ; and SCP 1 , 33 . 3 % . ^^^ |
|
| Interacting proteins: O60732 and P78358 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| To identify new CT antigens , we constructed an expression cDNA library from a melanoma cell line that expresses a wide range of CT antigens and screened the library with an allogeneic melanoma patient serum known to contain antibodies against two CT antigens , MAGE 1 and NY ESO 1 . cDNA clones isolated from this library identified four CT antigen genes : MAGE 4a , NY ESO 1 , LAGE 1 , and CT 7 . ^^^ LAGE 1 is a member of the NY ESO 1 gene family , and CT 7 is a newly defined gene with partial sequence homology to the MAGE family at its carboxyl terminus . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| Monophasic and biphasic synovial sarcomas abundantly express cancer / testis antigen NY ESO 1 but not MAGE A 1 or CT 7 . ^^^ The present study was performed to analyze the expression of 3 CT antigens , NY ESO 1 , MAGE A 1 and CT 7 , by immunohistochemistry with 3 monoclonal antibodies ( MAbs ) , ES 121 ( anti NY ESO 1 ) , MA 454 ( anti MAGE A 1 ) and CT 7 33 ( anti CT 7 ) , in 25 synovial sarcomas ( 12 MSS , 13 BSS ) typed for the t ( 10 ; 18 ) derived fusion transcript by RT PCR ( 19 SYT SSX 1 , 6 SYT SSX 2 ) . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| From a panel of eleven CTA ( MAGE 1 , MAGE C 1 , MAGE 3 , BAGE , GAGE , SSX 1 , SSX 2 , SSX 4 , SCP 1 , NY ESO 1 and TS 85 ) ( HOM Tes 85 ) , mRNA expression could be detected for SCP 1 in 8 / 17 MF and 6 / 8 pleomorphic CTCL patients but was completely absent in small plaques parapsoriasis . ^^^ SS patients had a more heterogeneous antigen expression pattern : Gage ( 1 / 11 ) , MAGE 1 ( 3 / 11 ) , MAGE 3 ( 6 / 11 ) , MAGE C 1 ( 5 / 11 ) , NY ESO 1 ( 7 / 11 ) and TS 85 ( 5 / 11 ) , with expression of MAGE 3 confirmed by immunohistochemistry . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| In the present study , 54 sarcoma patients were tested for serum antibodies to NY ESO 1 , SSX 2 , MAGE A 1 , MAGE A 3 , MAGE A 4 , MAGE A 10 , CT 7 , and CT 10 . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| Expression of cancer / testis ( CT ) antigens MAGE A 1 , MAGE A 3 , MAGE A 4 , CT 7 , and NY ESO 1 in malignant gammopathies is heterogeneous and correlates with site , stage and risk status of disease . ^^^ We examined the expression of a panel of CT antigenic proteins in 29 patients with malignant gammopathies by immunohistochemistry using the following monoclonal antibodies ( mAbs ) : mAb MA 454 to MAGE A 1 , mAb M3H67 to MAGE A 3 , mAb 57B to MAGE A 4 , mAb CT 7 33 to CT7 / MAGE C 1 and mAb ES 121 to NY ESO 1 . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| The following anti CT monoclonal antibodies / antigens were studied by immunohistochemistry : monoclonal antibody ES121 / NY ESO 1 , monoclonal antibody M3H67 / MAGE A 3 , monoclonal antibody 57B / MAGE A 4 , and monoclonal antibody CT 7 33 / CT7 . ^^^ CT antigens CT 7 , MAGE A 3 and MAGE A 4 , but not NY ESO 1 , are expressed in high grade endometrial carcinomas , and expression of MAGE A 4 is correlated with the presence of overexpressed p53 . . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression frequencies of CT antigens in tumor tissue were : MAGE A 1 , 69 . 9 % ; MAGE A 3 , 47 . 9 % ; MAGE A 4 , 20 . 0 % ; MAGE A 10 , 36 . 7 % ; SSX 1 , 67 . 4 % ; SSX 2 , 35 . 6 % ; SSX 4 , 48 . 8 % ; SSX 5 , 30 . 2 % ; NY ESO 1 , 42 . 5 % ; MAGE B 1 , 52 . 0 % ; MAGE B 2 , 60 . 0 % ; MAGE C 1 , 48 . 0 % ; MAGE C 2 , 68 . 0 % ; and SCP 1 , 33 . 3 % . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| In 98 evaluable cases , SCP 1 and SSX 4 were expressed most frequently ( both 65 % ) , followed by HOM TES 85 / CT 8 ( 47 % ) , GAGE ( 26 % ) , SSX 1 ( 20 % ) , NY ESO 1 ( 13 % ) , MAGE 3 ( 11 % ) , SSX 2 ( 8 % ) , CT 10 ( 7 % ) , MAGE 4 ( 4 % ) and CT 7 ( 1 % ) . ^^^ Of 100 serum samples screened for CT antigen specific antibodies , antibodies against NY ESO 1 were detected in 4 patients , against SCP 1 in 6 patients and against SSX 2 in 1 patient , while no antibodies were detected against MAGE 3 , CT 7 and CT 10 . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated the IgG antibody response against 11 cancer testis antigens ( SCP 1 , GAGE , LAGE 1a , 1b , CT 7 , NY ESO 1 , SSX 1 5 ) recombinantly expressed on yeast surface ( RAYS ) in patients with pancreatic cancer ( n = 96 ) , chronic pancreatitis ( n = 18 ) and healthy donors ( n = 48 ) . ^^^ We found in 14 % of all patients antibody responses to SCP 1 , but not to other cancer testis antigens ( GAGE , LAGE 1a , 1b , CT 7 , NY ESO 1 , SSX 1 5 ) . ^^^ |
|
| Interacting proteins: P78358 and O60732 |
Pubmed |
SVM Score :0.0 |
| NA |
|