| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND . p 13 ( suc 1 ) from fission yeast is a member of the CDC 28 kinase specific ( CKS ) class of cell cycle control proteins , that includes CKS 1 from budding yeast and the human homologues CksHs 1 and CksHs 2 . p 13 ( suc 1 ) participates in the regulation of p 34 ( cdc 2 ) , a cyclin dependent kinase controlling the G 1 S and the G 2 M transitions of the cell cycle . ^^^ |
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| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| At mitosis , mutant p 53 proteins interfere with the control of the metaphase to anaphase progression by up regulating the expression of CKs 1 , a protein that mediates activatory phosphorylation of the anaphase promoting complex ( APC ) by Cdc 2 . ^^^ |
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| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this altered mitotic spindle checkpoint status was associated with the overexpression of Cks 1 , a Cdc 2 adapter protein that promotes cyclin B degradation . ^^^ |
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| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| A kinase independent function of Cks 1 and Cdk 1 in regulation of transcription . ^^^ We describe a function in transcription for the Saccharomyces cerevisiae cell cycle regulatory cyclin dependent kinase Cdc 28 ( Cdk 1 ) and its interacting protein , Cks 1 . ^^^ |
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| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| Transfection of Cks 1 siRNA down regulated Cdc 2 kinase activity and induced G2 / M arrest in Cks 1 overexpressing H 358 lung cancer cells . ^^^ |
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| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| We provide evidence that FoxM 1 is essential for transcription of Skp 2 and Cks 1 , which are specificity subunits of the Skp 1 Cullin 1 F box ( SCF ) ubiquitin ligase complex that targets these CDKI proteins for degradation during the G ( 1 ) / S transition . ^^^ |
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| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| A high expression of CCNB 1 ( cyclin B 1 ) , CDC 2 , CDKN3A , CKS1B , ANP32E , and KIAA 0101 , but not of the proliferation related antigen Ki 67 , was associated with better survival rate in a univariate analysis . ^^^ |
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| Interacting proteins: P61024 and P06493 |
Pubmed |
SVM Score :0.0 |
| For analyzing relationships of CKS with cell proliferation and / or with differentiation , we investigated the expression of ckshs 1 and ckshs 2 in normal and malignant human lymphoid cells . ckshs 1 and ckshs 2 expression appeared to be related to cell proliferation : ( 1 ) mRNAs increased with stimulation of normal peripheral blood lymphocytes , and from the G 1 to the SG2M phase in elutriated cells ; ( 2 ) P 9 proteins were also induced by lymphocyte stimulation and were localized in nucleus where phosphorylated forms of CDK 1 were also found ; ( 3 ) in vitro , the phosphorylated forms of CDK 1 and CDK 2 were preferentially linked to CKS . ^^^ |
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