| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| This study showed that the age of 2 months appears to be a turning point in the development of digestive secretions , an age when the risk of SIDS is at its peak , and that the rates of the selected biological markers are significantly higher in victims of SIDS or ALTE than in controls . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| We report a case series of 25 full term infants , prospectively obtained from a database of nearly 700 `` apparent life threatening event ' ' ( ALTE ) cases , who presented between 3 weeks and 4 1 / 2 months of age an ALTE and who progressively developed more florid symptomatology and polygraphic findings . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Between January 1982 and June 1989 in South Australia 19 infants under 2 years of age have had serious sequelae following an apparent life threatening event ( ALTE ) for which no cause could be identified . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Normal developmental decreases of localized movements ( LMs ) on mental muscle with age were insufficient in ALTE . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Two ALTE infants have been recorded at 2 months as well as at 6 months of age . ^^^ In the ALTE cases at 2 months of age , the motility was quantitatively not different from the control infants but was markedly reduced at 6 months of age . ( All cases had their event before 8 weeks of age . ) In contrast to these findings , infants with repeated apnoea did not show a clear change in the quantity of their movements . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| We assessed 92 patients ( median gestational age at birth , 32 weeks ( range , 24 to 36 weeks ) ; median birth weight , 1840 gm ( 650 to 3500 gm ) ) who had had a single ( n = 20 ) or recurrent ALTE . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| All infants were at least 8 months of age at follow up and information concerning the occurrence of any ALTE was obtained by direct parent interview . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Nineteen infants with ALTE ( mean age : 4 . 3 months ) were brought to our hospital between June 1986 and August 1991 . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| METHODS : Thirty four polygraphic recordings of combined esophageal pH study and respiration in infants with ALTE , age 4 . 1 + / 4 . 9 months , range 0 . 4 27 months , were studied . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| TRAMP mice characteristically express the T antigen oncoprotein by 8 weeks of age and develop distinct pathology in the epithelium of the dorsolateral prostate by 10 weeks of age . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| In 180 healthy infants between 5 days and 18 months of age we performed respiratory CO 2 responses during NREM sleep and studied the immediate response to inhalation of 60 % oxygen ( Dejours test ) as well as in 8 children with congenital central alveolar hypoventilation syndrome ( CCHS ) and 15 infants who experienced an apparently life threatening event ( ALTE ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| TRAMP males develop histological prostatic intraepithelial neoplasia by 8 12 weeks of age that progress to adenocarcinoma with distant metastases by 24 30 weeks of age . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| TRAMP mice display high grade prostatic intraepithelial neoplasia or well differentiated prostate cancer by 10 12 weeks of age . ^^^ These results demonstrate that prostate cancer in the TRAMP model is heterogeneous with respect to androgen dependence as early as 12 weeks of age ; therefore , early androgen ablation may have a variable impact on progression in an individual mouse . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| The first ALTE occurred at a median age corrected for the expected date of delivery of 3 . 6 months in the CVS patients and of 0 . 3 months in controls . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| METHODS : 39 infants with a mean age of 10 . 6 + / 10 . 2 weeks ( 6 days to 11 months ) with apparent life threatening events ( ALTE ) were investigated by cranial Doppler sonography . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| After castration at 12 weeks of age , the TRAMP mice developed androgen independent prostate cancer ( AIPC ) and lymph node metastasis at 18 to 24 weeks of age . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Treatment of TRAMP mice at 14 weeks of age resulted in a significant reduction in tumor incidence ( 15 % versus control , 75 % ) , as assessed 2 months after treatment . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| This study compares the urinary excretion of the main melatonin metabolite , 6 sulfatoxymelatonin ( 6SMT ) , in infants who have and have not experienced a life threatening event ( ALTE ) . 6SMT was assessed in the following groups of infants : 15 infants with ALTE for whom home monitoring had been recommended , 15 infants who had had an abrupt cyanotic apneic event but did not require mouth to mouth resuscitation , 15 siblings of those who had died from sudden infant death syndrome ( SIDS ) , and 35 age matched healthy comparison infants . ^^^ Follow up of the ALTE infants , performed 6 to 8 weeks later ( 59 to 66 weeks of postconceptional age ) , revealed that 6SMT excretion increased in all of them , suggesting a delayed ontogeny rather than permanent deficiency of melatonin production in ALTE . . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Transgenic adenocarcinoma mouse prostate ( TRAMP ) is an excellent model of prostate cancer that mimics progressive forms of human disease inasmuch as 100 % of males develop histological PIN by 8 12 weeks of age that progress to adenocarcinoma with distant site metastases by 24 28 weeks of age . ^^^ In two independent experiments , each consisting of 8 animals on test , the cumulative incidence of prostatic cancer development at 28 weeks of age in 16 untreated TRAMP mice was 100 % ( 16 of 16 ) , whereas 94 % ( 15 of 16 ) and 69 % ( 11 of 16 ) of the animals exhibited distant site metastases to lymph nodes and lungs , respectively . ^^^ Oral consumption of 1 % DFMO ( w / v ) in the drinking water to TRAMP mice from 8 to 28 weeks of age resulted in a significant decrease in ( a ) weight ( 59 % ) and volume ( 66 % ) of prostate , ( b ) genitourinary weight ( 63 % ) , and ( c ) ODC enzyme activity ( 52 % ) in the dorsolateral prostate . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Using cDNA cloning , single stranded conformation polymorphism and sequencing strategies , 15 unique somatic mutations in the AR were identified in prostate tumors obtained from eight TRAMP mice between 24 and 29 weeks of age . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Fifty infants with ALTE were compared with 50 age and sex matched controls . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| In the transgenic adenocarcinoma of the mouse prostate ( TRAMP ) model of prostate cancer , tumors develop between 19 and 25 weeks of age . ^^^ Murine PSCA was strongly expressed on approximately 60 % of the cells of TRAMP tumors , at an age where the number of PSCA+ cells and the level of expression of PSCA is very low in the normal prostate . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| However , 0 . 1 % GTP ( wt / vol ) provided as the sole source of drinking fluid to TRAMP mice from 8 to 32 weeks of age resulted in ( 1 ) significant delay in primary tumor incidence and tumor burden as assessed sequentially by MRI , ( 2 ) significant decrease in prostate ( 64 % ) and genitourinary ( GU ) ( 72 % ) weight , ( 3 ) significant inhibition in serum insulin like growth factor 1 and restoration of insulin like growth factor binding protein 3 levels , and ( 4 ) marked reduction in the protein expression of proliferating cell nuclear antigen ( PCNA ) in the prostate compared with water fed TRAMP mice . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| By 28 30 weeks of age , all TRAMP mice in the study had developed prostate tumors , with about half of them displaying well differentiated prostatic adenocarcinoma ( WD , score 4 ) , and the other half divided between moderately differentiated ( MD , score 5 ) and poorly differentiated adenocarcinoma ( PD , score 6 ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| DESIGN : A 12 month prospective study of infants under 1 year of age who presented to a children ' s hospital ED after an ALTE . ^^^ More serious diagnoses were associated with a presentation age over 2 months , abnormal initial clinical examination , and recurrent ALTE . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| We performed six to eight 45 degrees head up tilts in 10 ALTE infants ( age , 14 + / 3 weeks ) and 12 age matched control subjects during slow wave sleep and rapid eye movement sleep ( REM ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| In this case control study , 40 full term ALTE infants , aged 2 36 wk at the time of the event , were compared with 40 age and sex matched randomly selected controls . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| METHODS : Children who were younger than 24 months of age and presented to the emergency department between March 1 , 1997 , and February 28 , 1999 , with signs and symptoms consistent with the National Institutes of Health ' s definition of an ALTE were studied prospectively . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| The study included eighty nine infants ( age 2 . 14 + / 1 . 8 months , 46 males and 43 females ) referred with ALTE to the pediatric emergency room and 18 controls ( age 2 . 77 + / 2 . 2 months ) who underwent electrocardiogram assessment of QTmin , QTmax , QT dispersion ( QT D ) , and as well as QTmin , QTmax , and QT D corrected for heart rate ( QTcmin , QTcmax , QTC D , respectively ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Using this grading scheme , we assessed lesion development in ad libitum fed and 20 % diet restricted groups of TRAMP ( Transgenic Adenocarcinoma of Mouse Prostate ) mice that were started on study at 7 weeks of age and sacrificed when 11 and 20 weeks old . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| The transgenic adenocarcinoma of the mouse prostate ( TRAMP ) model displays spontaneous tumor development with age and metastasizes to tissues similar to human prostate cancer . ^^^ METHODS : A sensitive , real time quantitative PCR assay was developed to measure Folh 1 cRNA copy number in various tissues of 30 32 week old TRAMP+ and age matched , nontransgenic controls ( TRAMP ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| When TRAMP mice were treated systemically for 10 weeks , the incidence of palpable tumors at 32 weeks of age in untreated mice or mice injected with the control scramble oligonucleotide was 87 % , whereas incidence of tumors in antisense Egr 1 treated mice was significantly reduced to 37 % ( P=0 . 026 ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| In our early intervention trial , administration of SU 5416 to TRAMP mice did not appear to influence angiogenesis or tumor progression between 10 and 16 weeks of age , a time corresponding to high levels of VEGFR 1 expression . ^^^ In our late intervention trial , however , we observed a significant decrease in tumor associated mean vessel density , increased apoptotic index , and pronounced regions of cell death when SU 5416 was administered to TRAMP mice between 16 and 22 weeks of age , a time corresponding to high levels of VEGFR 2 expression . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| RESULTS : High FAS expression and activity in the TRAMP mouse prostate was evident at 12 weeks of age compared with nontransgenic littermates and further increased with age , tumor progression , and in metastatic lesions . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Mean [ gamma / ( gamma+beta ) ] globin mRNAs were increased in the ALTE group at 42 to 45 and 46 to 49 weeks of postconceptional age ( mean : 55 . 2 + / 17 . 4 % and 33 . 9 + / 14 % ) in comparison with HbF synthesis in controls ( mean : 42 . 6 + / 13 . 7 % and 23 . 6 + / 9 . 8 % ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Patients under 6 months of age were identified for a potential ALTE from the ED chief complaint log . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| The basal enzyme activity and protein expression of COX 2 is significantly higher ( > 4 fold ) in the dorsolateral prostate of TRAMP mice up to 24 weeks of age compared with their nontransgenic littermates . ^^^ Celecoxib supplementation to TRAMP mice from 8 32 weeks of age exhibited significant reduction in tumor development ( 5 of 20 ) with no signs of metastasis . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| In order to understand the mechanism of action of genistein , we have investigated the expression of androgen and estrogen receptors , four growth factor receptors that signal via tyrosine protein kinases , and specific growth factor proteins in the dorsolateral prostates of TRAMP mice fed 250 mg genistein / kg diet , starting at 5 weeks of age . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| At 30 weeks of age , the average genitourinary tract weights of TRAMP mice were approximately 4 times greater than those of TRAMP / SSAT bigenic mice , and by 36 weeks , they were approximately 12 times greater indicating sustained suppression of tumor outgrowth . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Our data demonstrated an increase in the levels of IGF 1 , phosphatidylinositol 3 ' kinase , phosphorylated Akt ( Thr 308 ) , and extracellular signal regulated kinase 1 / 2 with concomitant decrease in IGFBP 3 in dorso lateral prostate of TRAMP mice during the course of cancer progression , i . e . , as a function of age . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : Male TRAMP mice 8 weeks of age were equally divided into two groups . ^^^ RESULTS : With the progression of age and prostate cancer growth in TRAMP mice , an increase in the expression of S100A4 at mRNA and protein level in dorsolateral prostate , but not in nontransgenic mice , occurred . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Of various SIDS risk factors in the survey area , the prone sleeping position , smoking during pregnancy , low gestational age , profuse night sweating , and family history of infant death showed a moderate relation to the risk of overall ALTE , but only smoking maintained significance in the multivariate risk model . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| The neurological long term sequelae of an idiopathic apparent life threatening event ( ALTE ) were studied in 14 ALTE cases and 12 controls ( of similar sex , age , and maturation of puberty ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Male TRAMP mice were maintained on an ad libitum diet until 20 weeks of age when proliferative prostate lesions are clearly evident . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| From 5 to 28 wk of age , 80 , 68 , and 30 TRAMP mice were fed AIN 76A diet containing 0 , 250 , or 500 mg genistein / kg body weight , respectively . ^^^ OPN was upregulated 10 fold in PD compared with prostates with a lower pathological score from TRAMP or NTM of any age ( P = 0 . 003 ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Tissues of accessory sex organs harvested from 72 TRAMP mice of various ages ( 11 40 weeks of age ) were fixed in neutral buffered formalin and stained with hematoxylin and eosin , desmin , 5 bromo 2 ' deoxyuridine ( BrdU , treated animals only ) , and SV 40 Large T antigen ( SV 40 Tag ) . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| RESULT : We show , for the first time , that oxidative / nitrosative damages of genomic DNA and cellular proteins were discretely localized in premalignant lesions , but not in adjacent morphologically normal epithelia , of TRAMP prostates ; these injuries were absent in age matched nontransgenic littermates . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Specifically , the authors sought to prospectively describe hemoglobin ( Hb ) levels and mean corpuscular volumes ( MCVs ) in children presenting with either a single ALTE or recurrent events , and to compare the values with those of an age matched control population . ^^^ Overall , the ALTE and control patients were similar with regard to age , gender , and race . ^^^ Patients with recurrent ALTEs are older and have lower Hb , MCH , and MCV values than patients with a single ALTE and age matched control patients . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| TRAMP mice were fed a rye bran ( n = 13 ) or a control diet ( n = 15 ) from 4 to 24 wk of age . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| Interestingly , when TRAMP mice were treated in a chemopreventive manner with the DNA methyltransferase inhibitor 5 aza 2 ' deoxycytidine ( 5 aza ) , 0 of 14 mice developed prostate cancer at 24 weeks of age , whereas 7 of 13 ( 54 % ) control treated mice developed poorly differentiated prostate cancer . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| We report the clinical presentation of a male patient who presented at the age of 4 months after an ALTE like event ( ALTE = acute life threatening event ) with febrile status epilepticus . ^^^ |
|
| Interacting proteins: P51606 and O96006 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To characterize the voiding function in a transgenic adenocarcinoma of murine prostate ( TRAMP ) mouse of advanced age , because it might provide a useful model of slow onset bladder outlet obstruction . ^^^ |
|