| Interacting proteins: Q00987 and P49407 |
Pubmed |
SVM Score :0.0 |
| In this study , we found that although both beta arrestin 1 and beta arrestin 2 are able to interact with ubiquitin protein isopeptide ligase ( E 3 ) Mdm 2 , only expression of beta arrestin 2 leads to the relocalization of Mdm 2 from the nucleus to the cytoplasm . ^^^ |
|
| Interacting proteins: Q00987 and P49407 |
Pubmed |
SVM Score :0.0 |
| Insulin stimulated the association of IRS 1 and Mdm 2 , an E 3 ubiquitin ligase , and this association was inhibited to overexpression of WT beta arrestin 1 , which led by decreased ubiquitin content of IRS 1 , suggesting that both beta arrestin 1 and IRS 1 competitively bind to Mdm 2 . ^^^ In summary , we have found the following : ( 1 ) beta arrestin 1 can alter insulin signaling by inhibiting insulin induced proteasomal degradation of IRS 1 ; ( 2 ) beta arrestin 1 decreases the rate of ubiquitination of IRS 1 by competitively binding to endogenous Mdm 2 , an E 3 ligase that can ubiquitinate IRS 1 ; ( 3 ) dephosphorylation of S 412 on beta arrestin and the amino terminus of beta arrestin 1 are required for this effect of beta arrestin on IRS 1 degradation ; and ( 4 ) inhibition of beta arrestin 1 leads to enhanced IRS 1 degradation and accentuated cellular insulin resistance . . ^^^ |
|
| Interacting proteins: Q00987 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|