| Interacting proteins: P34981 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34981 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34981 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P34981 and P49407 |
Pubmed |
SVM Score :0.0 |
| Expression of either beta arrestin 1 or 2 promoted TRHR 1 internalization . ^^^ The preference for beta arrestin 2 by TRHR 2 was supported by the impairment of TRHR 2 trafficking in mouse embryonic fibroblasts ( MEFs ) from either a beta arrestin 2 knockout or a beta arrestin 1 / 2 knockout , while TRHR 1 trafficking was only abolished in MEFs lacking both beta arrestins . ^^^ The formation of TRHR1 / 2 heteromeric complexes increased the interaction between TRHR 2 and beta arrestin 1 . ^^^ This may be due to conformational differences between TRHR1 / 2 hetero oligomers versus TRHR 2 homo oligomers as a mutant TRHR 1 ( TRHR 1 C335Stop ) that does not interact with beta arrestins , could also enhance TRHR2 / beta arrestin 1 interaction . ^^^ |
|