| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| Clathrin mediated endocytosis of the beta adrenergic receptor is regulated by phosphorylation / dephosphorylation of beta arrestin 1 . beta Arrestins serve a dual regulatory role in the life cycle of G protein coupled receptors such as the beta 2 adrenergic receptor . ^^^ |
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| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| The functions of beta arrestin 1 to facilitate clathrin mediated endocytosis of the beta 2 adrenergic receptor and to promote agonist induced activation of extracellular signal regulated kinases ( ERK ) are regulated by its phosphorylation / dephosphorylation at Ser 412 . ^^^ Under such conditions , beta arrestin 1 mediated beta 2 adrenergic receptor internalization is enhanced as is its ability to bind clathrin . ^^^ |
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| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| We have previously identified c SRC as a molecule that is rapidly recruited to the beta 2 adrenergic receptor in a beta arrestin 1 dependent manner . ^^^ |
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| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| Beta Arrestin 1 down regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3 L 1 adipocytes . beta Arrestin 1 is required for internalization and mitogen activated protein ( MAP ) kinase activation by the beta 2 adrenergic receptor ( beta2AR ) . ^^^ |
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| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| The overexpression of either the beta arrestin 1 V53D dominant negative inhibitor of beta2AR sequestration or dynamin 1 K44A to block clathrin coated vesicle mediated endocytosis impaired both beta2AR dephosphorylation and resensitization . ^^^ In contrast , resensitization of a sequestration impaired beta2AR mutant ( Y326A ) was reestablished following the overexpression of either GRK 2 or beta arrestin 1 . ^^^ |
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| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| Internalization of the beta2AR chimera bearing the AT1AR tail was observed in the absence of agonist and was inhibited by a dominant negative beta arrestin 1 mutant . ^^^ |
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| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| In summary , contrary to data obtained for the beta2AR , the constitutive activation of the TSHR does not influence the desensitization and time course for internalization of the receptor , and in agreement with findings for the FSH and LH receptors , these results characterize the TSH receptor as a member of the class A of G protein coupled receptors , which have a higher affinity to beta arrestin 2 than beta arrestin 1 and do not colocalize with beta arrestins in endosomes . . ^^^ |
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| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07550 and P49407 |
Pubmed |
SVM Score :0.0 |
| NA |
|