| Moreover , GIT 1 localizes to neuronal inclusions , and is selectively cleaved in HD brains , indicating that its distribution and function is altered during disease pathogenesis . . ^^^ A protein interaction network links GIT 1 , an enhancer of huntingtin aggregation , to Huntington ' s disease . ^^^ The network also permitted the functional annotation of 16 uncharacterized proteins and facilitated the discovery of GIT 1 , a G protein coupled receptor kinase interacting protein , which enhances huntingtin aggregation by recruitment of the protein into membranous vesicles . ^^^ Coimmunoprecipitations and immunofluorescence studies revealed that GIT 1 and huntingtin associate in mammalian cells under physiological conditions . ^^^ |