| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| We report the discovery of the huntingtin interacting protein 1 ( HIP 1 ) which binds specifically to the N terminus of human huntingtin , both in the two hybrid screen and in in vitro binding experiments . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| With the yeast two hybrid system , one such interacting factor , the huntingtin interacting protein 1 ( HIP 1 ) , was identified ( Wanker et al . 1997 ; Kalchman et al . 1997 ) and the human gene mapped to 7q11 . 2 . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Fusion of Huntingtin interacting protein 1 to platelet derived growth factor beta receptor ( PDGFbetaR ) in chronic myelomonocytic leukemia with t ( 5 ; 7 ) ( q 33 ; q11 . 2 ) . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Here we report the isolation of a cDNA clone for HIP1R ( huntingtin interacting protein 1 related ) , which encodes a predicted protein product sharing a striking homology with HIP 1 . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis of subcellular membrane fractions separated by differential centrifugation confirmed that huntingtin immunoreactivity in differentiated neurons markedly increased in membrane fractions enriched with clathrin and with huntingtin interacting protein 1 . ^^^ Results suggest that the transport of huntingtin and its co expression in clathrin and huntingtin interacting protein 1 enriched membranes is influenced by activation of adenylyl cyclase and stimulation of dopamine D 1 receptors . . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Transforming properties of the Huntingtin interacting protein 1 / platelet derived growth factor beta receptor fusion protein . ^^^ We have previously reported that the Huntingtin interacting protein 1 ( HIP 1 ) gene is fused to the platelet derived growth factor beta receptor ( PDGFbetaR ) gene in a patient with chronic myelomonocytic leukemia . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| An actin binding protein of the Sla2 / Huntingtin interacting protein 1 family is a novel component of clathrin coated pits and vesicles . ^^^ Here , we have cloned and characterized mHip1R , a protein that is closely related to huntingtin interacting protein 1 ( Hip 1 ) . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 1 induces apoptosis via a novel caspase dependent death effector domain . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 1 ( HIP 1 ) is a membrane associated protein that interacts with huntingtin , the protein altered in Huntington disease . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| It has been shown previously that the Huntingtin interacting protein 1 gene ( HIP 1 ) was fused to the platelet derived growth factor beta receptor gene ( PDGFbetaR ) in leukemic cells of a patient with chronic myelomonocytic leukemia . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| This mutation influences the interaction of huntingtin with different proteins , including huntingtin interacting protein 1 ( HIP 1 ) , in which affinity to bind to mutant huntingtin is profoundly reduced . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Here , we show that huntingtin interacting protein 1 ( HIP 1 ) , a binding partner of huntingtin , copurifies with brain clathrin coated vesicles and associates directly with both AP 2 and clathrin . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| The resultant fusion proteins have constitutive PDGFbetaR tyrosine kinase activity , but the partner genes previously reported ( tel , Huntingtin interacting protein 1 [ HIP 1 ] , H4 / D10S170 ) have poorly understood roles in the oncogenic activity of the fusion proteins . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors . ^^^ Huntingtin interacting protein 1 ( HIP 1 ) interacts with huntingtin , the protein whose gene is mutated in Huntington ' s disease . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| The viral death protein Apoptin interacts with Hippi , the protein interactor of Huntingtin interacting protein 1 . ^^^ In an attempt to elucidate the molecular mechanism of Apoptin induced apoptosis , we identified human Hippi , the protein interactor and apoptosis co mediator of Huntingtin interacting protein 1 , as one of the Apoptin associated proteins by yeast two hybrid screen . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Altered receptor trafficking in Huntingtin Interacting Protein 1 transformed cells . ^^^ The clathrin associated protein , Huntingtin Interacting Protein 1 ( HIP 1 ) , is overexpressed in multiple human epithelial tumors . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 1 ( HIP 1 ) is a recently identified component of clathrin coated vesicles that plays a role in clathrin mediated endocytosis . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Increased expression of the Huntingtin interacting protein 1 gene in cells from Hutchinson Gilford Syndrome ( Progeria ) patients and aged donors . ^^^ Expression of huntingtin interacting protein 1 ( HIP 1 ) gene was found to be increased not only in PG cells but also in fibroblast cells from aged healthy donors . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis , spinal defects and cataracts . ^^^ Huntingtin Interacting Protein 1 ( HIP 1 ) binds clathrin and AP 2 , is overexpressed in multiple human tumors , and transforms fibroblasts . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Here , we summarize the information known about huntingtin interacting protein 1 ( HIP 1 ) , an endocytic protein with transforming properties that is involved in a cancer causing translocation and which is overexpressed in a variety of human cancers . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| In mice and humans , there are two known members of the Huntingtin interacting protein 1 ( HIP 1 ) family , HIP 1 and HIP 1 related ( HIP1r ) . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 1 ( HIP 1 ) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain . ^^^ Huntingtin interacting protein 1 ( HIP 1 ) is a component of clathrin coats . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| In this report , we have determined the affinity of the I / LWEQ module proteins Talin 1 , Talin 2 , huntingtin interacting protein 1 ( Hip 1 ) , and the Hip 1 related protein ( Hip1R / Hip12 ) for F actin and identified a conserved structural element that interferes with the actin binding capacity of these proteins . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein 1 related gene for anticipation in bipolar affective disorder . ^^^ We report here investigation of the stability of intergenerational transmission of a variable number tandem repeat ( VNTR ) polymorphism , found in the Huntingtin interacting protein 1 related gene ( HIP12 / HIP1R ) that is mapped to the chromosome 12q24 . 31 region , in nine pedigrees showing decreased age at onset in successive generations . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Serum antibodies to huntingtin interacting protein 1 : a new blood test for prostate cancer . ^^^ Huntingtin interacting protein 1 ( HIP 1 ) is frequently overexpressed in prostate cancer . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk 1 and caspase 3 in hippocampal neuroprogenitor cells . ^^^ Huntingtin interacting protein 1 ( Hip 1 ) , a proapoptotic mediator , is implicated as a molecular accomplice in the pathogenesis of Huntington ' s disease . ^^^ |
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| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors . ^^^ One of these adaptor proteins , huntingtin interacting protein 1 ( HIP 1 ) , induces cellular transformation and is overexpressed in some prostate cancers . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Now , new data demonstrate that huntingtin interacting protein 1 ( HIP 1 ) , an endocytic protein , modulates the transcriptional activity of nuclear hormone receptors . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 1 mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations . ^^^ Huntingtin interacting protein 1 ( Hip 1 ) is known to be associated with the N terminal domain of huntingtin . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Here , we identified the p231HBP protein as a DNA binding factor , the C terminal portion of which has recently been characterized as the huntingtin interacting protein HYPB of unknown function . ^^^ Identification of the full length huntingtin interacting protein p231HBP / HYPB as a DNA binding factor . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| Among these , we identified a major interactor class , comprising three distinct WW domain proteins , HYPA , HYPB and HYPC , that bind normal and mutant huntingtin in extracts of HD lymphoblastoid cells . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| These are revealed to be related spliceosome proteins ( HYPA / FBP 11 and HYPC ) and a transcription factor ( HYPB ) that implicate huntingtin in mRNA biogenesis . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| The HSPC069 / HYPB gene was originally isolated from the human hematopoietic stem / progenitor cells ( HSPCs ) , and it was also identified as a huntingtin interacting protein , implicated in the pathogenesis of Huntington disease ( HD ) . ^^^ Thus , our results suggest that HYPB HMTase may coordinate histone methylation and transcriptional regulation in mammals and open perspective for the further study of the potential roles of HYPB protein in hematopoiesis and pathogenesis of HD . . ^^^ Here we report the structural and functional characterization of the huntingtin interacting protein B ( HYPB ) . 1 ) The triplicate AWS SET PostSET domains mediate a histone H 3 lysine 36 specific HMTase activity . 2 ) A low charged region that is rich in glutamine and proline has been characterized as a novel transcriptional activation domain . ^^^ |
|
| Interacting proteins: Q9BYW2 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
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