| Interacting proteins: Q99963 and P42858 |
Pubmed |
SVM Score :0.5318134 |
| EEN , identified initially as a fusion partner to the mixed lineage leukaemia gene in human leukaemia , and its related members , EEN B 1 and EEN B 2 , have recently been shown to interact with two endocytic molecules , dynamin and synaptojanin , as well as with the huntingtin protein . 0.5318134^^^ |
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| Interacting proteins: Q99963 and P42858 |
Pubmed |
SVM Score :0.0 |
| Intriguingly , expression of huntingtin , another polyglutamine protein interacting with endophilin A 3 , was also toxic in Deltasac 6 yeast . ^^^ |
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| Interacting proteins: Q99963 and P42858 |
Pubmed |
SVM Score :0.0 |
| Characterization of the mouse Src homology 3 domain gene Sh3d2c on Chr 7 demonstrates coexpression with huntingtin in the brain and identifies the processed pseudogene Sh3d2c ps 1 on Chr 2 . ^^^ Because huntingtin and Sh3d2c are coexpressed in most regions of the brain , it can be speculated that there is a link between the association of huntingtin / Sh3d2c and the pathogenesis of Huntington disease . . ^^^ |
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| Interacting proteins: Q99963 and P42858 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the SH3GL3 protein , which is preferentially expressed in brain and testis , selectively interacts with the HD exon 1 protein ( HDex1p ) containing a glutamine repeat in the pathological range and promotes the formation of insoluble polyglutamine containing aggregates in vivo . ^^^ Additionally , an anti SH3GL3 antibody was also able to coimmunoprecipitate the full length huntingtin from an HD human brain extract . ^^^ The characteristics of the interaction between SH3GL3 and huntingtin and the colocalization of the two proteins suggest that SH3GL3 could be involved in the selective neuronal cell death in HD . . ^^^ SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln containing protein aggregates . ^^^ |
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| Interacting proteins: Q99963 and P42858 |
Pubmed |
SVM Score :0.0 |
| HSP 70 , proteasome , dynamin , and the htt binding partners htt interacting protein 1 ( HIP 1 ) , SH 3 containing Grb 2 like protein ( SH3GL3 ) , and 14 . 7K interacting protein were reduced in their normal location and redistributed to the shell . ^^^ Removal of a series of prolines adjacent to the polyglutamine region in htt blocked formation of the shell of the htt body and redistribution of dynamin , HIP 1 , SH3GL3 , and proteasome to it . ^^^ |
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