| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| FIP 2 , a coiled coil protein , links Huntingtin to Rab 8 and modulates cellular morphogenesis . ^^^ Here , we report that Huntingtin is linked to the Rab 8 protein through FIP 2 , a tumour necrosis factor alpha ( TNF alpha ) inducible coiled coil protein related to the NEMO protein [ 6 , 7 ] . ^^^ Huntingtin bound to the carboxy terminal region of FIP 2 . ^^^ Coexpressed FIP 2 and Huntingtin enhanced the recruitment of Huntingtin to Rab 8 positive vesicular structures , and FIP 2 promoted cell polarisation in a similar way to Rab 8 . ^^^ We propose a model in which Huntingtin , together with FIP 2 and Rab 8 , are part of a protein network that regulates membrane trafficking and cellular morphogenesis . . ^^^ |
|
| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| Extensive amino acid sequence similarity indicates that Ag 9C5 is likely the chicken homologue of a human protein , FIP 2 , which interacts with huntingtin and Rab 8 . ^^^ |
|
| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| Research in past years has identified several htt interacting proteins such as htt interacting protein 1 , Src homology region 3 containing Grb 2 like protein 3 , protein kinase C and casein kinase substrate in neurons 1 , htt associated protein 1 , postsynaptic density 95 , FIP 2 ( for 14 . 7K interacting protein ) , specificity protein 1 and nuclear receptor co repressor . ^^^ |
|
| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| Optineurin also functions through its interactions with other proteins in cellular morphogenesis and membrane trafficking ( RAB 8 ) , vesicle trafficking ( Huntingtin ) , transcription activation ( TFIIIA ) , and assembly or activity of two unknown kinases . ^^^ |
|
| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| Two further binding partners for optineurin have been identified : huntingtin and Rab 8 . ^^^ |
|
| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| We show here that mGluRs interact with the Htt binding protein optineurin that is also linked to normal pressure open angled glaucoma and , when expressed in HEK 293 cells , optineurin functions to antagonize agonist stimulated mGluR1a signaling . ^^^ We find that Htt is co precipitated with mGluR1a and that mutant Htt functions to facilitate optineurin mediated attenuation of mGluR1a signaling . ^^^ In addition , we show that a missense single nucleotide polymorphism optineurin H486R variant previously identified to be associated with glaucoma is selectively impaired in mutant Htt binding . ^^^ Although optineurin H486R retains the capacity to bind to mGluR1a , optineurin H486R dependent attenuation of mGluR1a signaling is not enhanced by the expression of mutant Htt . ^^^ Inhibition of metabotropic glutamate receptor signaling by the huntingtin binding protein optineurin . ^^^ |
|
| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| In addition to GRK mediated uncoupling of mGluRs from heterotrimeric G proteins , the huntingtin interacting protein , optineurin , also contributes to mGluR 1 and mGluR 5 desensitization . ^^^ The G protein uncoupling activity of optineurin appears to be facilitated by the presence of polyglutamine expanded mutant huntingtin but not wild type huntingtin . ^^^ |
|
| Interacting proteins: Q96CV9 and P42858 |
Pubmed |
SVM Score :0.0 |
| The OPTN gene codes for a conserved 66 kilodalton protein of unknown function that has been implicated in the tumor necrosis factor alpha signaling pathway and that interacts with diverse proteins including Huntingtin , Ras associated protein RAB 8 , and transcription factor IIIA . ^^^ |
|