| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Interference by huntingtin and atrophin 1 with cbp mediated transcription leading to cellular toxicity . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Although some CBP staining appeared as dots in the selective brain regions ( e . g . hypothalamus and amygdala ) , double labeling showed that most CBP was not co localized with huntingtin nuclear inclusions . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Cell death triggered by polyglutamine expanded huntingtin in a neuronal cell line is associated with degradation of CREB binding protein . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Mutant huntingtin represses CBP , but not p 300 , by binding and protein degradation . ^^^ We now report that the transcriptional activity of CBP is already repressed in the early time points by soluble mutant huntingtin , whereas the histone acetylase activity of CBP / p300 is gradually diminished over time . ^^^ Mutant huntingtin bound much stronger to CBP than normal huntingtin , possibly contributing to repression . ^^^ Thus , mutant huntingtin specifically affects CBP and not p 300 both at the early and later time points , via multiple mechanisms . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Mutant huntingtin represses CBP , but not p 300 , by binding and protein degradation . ^^^ We now report that the transcriptional activity of CBP is already repressed in the early time points by soluble mutant huntingtin , whereas the histone acetylase activity of CBP / p300 is gradually diminished over time . ^^^ Mutant huntingtin bound much stronger to CBP than normal huntingtin , possibly contributing to repression . ^^^ Thus , mutant huntingtin specifically affects CBP and not p 300 both at the early and later time points , via multiple mechanisms . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin . ^^^ Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein ( CBP ) or its recruitment into huntingtin aggregates . ^^^ Using a single cell based assay , we found that , in HT 22 cells or primary neurons transfected with mutant huntingtin , cell toxicity was accompanied by CBP depletion , rather than merely recruitment . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The patients with HD had the slowest RTs . ^^^ Across the two blocks with arbitrary S 1 S2 associations , the patients with HD but not PD nevertheless showed evidence of learning in their precued RTs . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Casual BP ( cBP ) was defined as the average of two measurements obtained at two HD sessions , one preceding and one following the ABP recordings , and was calculated for both the predialysis and postdialysis phases . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| In contrast , patients with HD demonstrated disproportionately longer RTs to inconsistent stimuli relative to their age matched control group . ^^^ Difference scores between RTs for inconsistent versus consistent stimuli were not correlated with overall level of dementia or disease severity for either the HD or PD group . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Expanded httex1p represses transcription of the p 53 regulated promoters , p 21 ( WAF1 / CIP1 ) and MDR 1 . httex1p was also found to interact in vitro with CREB binding protein ( CBP ) and mSin3a , and CBP to localize to neuronal intranuclear inclusions in a transgenic mouse model of HD . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| There is growing evidence that truncated forms of mutant Htt in the nucleus influence gene transcription by binding to proteins such as CREB binding protein ( CBP ) response element binding protein binding protein , N COR , glyceraldehyde 3 phosphate dehydrogenase , and p 53 . p 53 regulates the transcription of various mitochondrial proteins which may underlie the mitochondrial abnormalities , especially the vulnerability to mitochondrial depolarization , seen in HD tissues . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| HD transgenic mice develop an age dependent reduction of insulin mRNA expression and diminished expression of key regulators of insulin gene transcription , including the pancreatic homeoprotein PDX 1 , E2A proteins , and the coactivators CBP and p 300 . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Recent evidence has shown that the activity of cAMP responsive element binding protein ( CREB ) and of CREB binding protein ( CBP ) is decreased in Huntington ' s disease ( HD ) [ Steffan et al . ( 2000 ) Proc . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| To test whether human testis per se is more sensitive than rat testis to MAA , we compared the responses of cultured rat seminiferous tubules ( RSTs ) and human testicular tissues ( HTT ) in vitro . ^^^ |
|
| Interacting proteins: P42858 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Here we show that the polyglutamine containing domain of Htt , Htt exon 1 protein ( Httex1p ) , directly binds the acetyltransferase domains of two distinct proteins : CREB binding protein ( CBP ) and p300 / CBP associated factor ( P / CAF ) . ^^^ |
|