| Interacting proteins: Q8IUH5 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacting protein 14 is an oncogenic human protein : palmitoyl acyltransferase . ^^^ We show that the Huntingtin interacting protein 14 ( HIP 14 ) is a PAT with a preference for the farnesyl dependent palmitoylation motif found in H and N RAS . ^^^ |
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| Interacting proteins: Q8IUH5 and P42858 |
Pubmed |
SVM Score :0.0 |
| The palmitoylation and distribution of htt are regulated by the palmitoyl transferase huntingtin interacting protein 14 ( HIP 14 ) . ^^^ |
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| Interacting proteins: Q8IUH5 and P42858 |
Pubmed |
SVM Score :0.0 |
| HIP 14 protein is enriched in the brain , shows partial co localization with htt in the striatum , and is found in medium spiny projection neurons , the subset of neurons affected in HD . ^^^ Our findings suggest that decreased interaction between htt and HIP 14 could contribute to the neuronal dysfunction in HD by perturbing normal intracellular transport pathways in neurons . . ^^^ Using the yeast two hybrid system , we have isolated a novel htt interacting protein , HIP 14 . ^^^ HIP 14 ' s interaction with htt is inversely correlated to the poly ( Q ) length in htt . mRNAs of 9 and 6 bp are transcribed from the HIP 14 gene , with the 6 kb transcript being predominantly expressed in the brain . ^^^ HIP 14 , a novel ankyrin domain containing protein , links huntingtin to intracellular trafficking and endocytosis . ^^^ |
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| Interacting proteins: Q8IUH5 and P42858 |
Pubmed |
SVM Score :0.0 |
| Here , using biochemical assays , we show that huntingtin ( htt ) interacting protein , HIP 14 , is a neuronal palmitoyl transferase ( PAT ) . ^^^ HIP 14 shows remarkable substrate specificity for neuronal proteins , including SNAP 25 , PSD 95 , GAD 65 , synaptotagmin 1 , and htt . ^^^ Huntingtin interacting protein HIP 14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins . ^^^ |
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