| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.58189986 |
| HAP 1 , a protein that interacts with huntingtin ( Huntington ' s disease protein ) , has an expression profile that intriguingly mirrors the selective neurodegeneration seen in Huntington ' s disease . . 0.58189986^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.79743956 |
| HAP 1 ( huntingtin associated protein ) has previously been found to interact with huntingtin ( htt ) in a glutamine length dependent manner and has been proposed to play a role in the cell specific neurodegeneration observed in Huntington ' s disease ( HD ) . 0.79743956^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.86592666 |
| Huntingtin associated protein 1 ( HAP 1 ) , a brain enriched protein , interacts preferentially with mutant huntingtin and thus may be important in HD pathogenesis . 0.86592666^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.5336001 |
| Here we report that Htt interacts with ND via HAP 1 , and that MLK 2 phosphorylates and stimulates the activity of ND . 0.5336001^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| The HAP 1 protein is enriched in the brain , suggesting a possible basis for the selective brain pathology of HD . . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| HAP 1 is a neural protein and interacts with the Huntington ' s disease protein huntingtin . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein ( HAP 1 ) : discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase . ^^^ We recently identified a brain specific protein that associates with huntingtin and is designated huntingtin associated protein ( HAP 1 ) . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Fast transport and retrograde movement of huntingtin and HAP 1 in axons . ^^^ The huntingtin associated protein HAP 1 and the retrograde motor protein dynein also accumulated on both sides of the crush , whereas the vesicle docking protein SNAP 25 was elevated only proximally . ^^^ The rapid anterograde accumulation of huntingtin and HAP 1 is compatible with their axonal transport on vesicular membranes . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| The selective degeneration and neuronal morphologic abnormalities of HD may involve interactions with proteins that bind to huntingtin , such as HAP 1 . ^^^ Huntingtin associated protein 1 ( HAP 1 ) binds to a Trio like polypeptide , with a rac 1 guanine nucleotide exchange factor domain . ^^^ The biological significance of this interaction is unclear because neither HAP 1 nor huntingtin have significant homology to known proteins . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Thus , HAP 1 and huntingtin may play a role in vesicle trafficking within the cell and disruption of this function could contribute to the neuronal dysfunction and death seen in HD . . ^^^ Huntingtin associated protein 1 ( HAP 1 ) interacts with the p150Glued subunit of dynactin . ^^^ We previously identified a protein ( HAP 1 ) which binds to huntingtin in a glutamine repeat length dependent manner . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein ( HAP 1 ) is a neuronal protein and binds to huntingtin in association with the polyglutamine repeat . ^^^ Like huntingtin , HAP 1 has been found to be a cytoplasmic protein associated with membranous organelles , suggesting the existence of a protein complex including HAP 1 , huntingtin , and other proteins . ^^^ An in vitro binding assay showed that both huntingtin and P 150 selectively bound to a glutathione transferase ( GST ) HAP 1 fusion protein . ^^^ An immunoprecipitation assay demonstrated that P 150 and huntingtin coprecipitated with HAP 1 from rat brain cytosol . ^^^ Western blot analysis revealed that HAP 1 was enriched in rat brain microtubules and comigrated with P 150 and huntingtin in sucrose gradients . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Although the function of huntingtin is still unknown , several associated proteins such as HAP 1 , Ubiquitin conjugating enzyme , HIP 1 and glyceraldehyde 3 phosphate dehy dorogenase ( GAPDH ) were reported . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| The selective neuropathology in HD is thought to be mediated in part through interactions with other proteins including the Huntington Associated Protein , HAP 1 , which is predominantly expressed in the brain . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Identification of the human homologue of HAP 1 is necessary for investigation of the potential role of HAP 1 in HD pathology . ^^^ We previously identified a rat huntingtin associated protein ( HAP 1 ) that binds to huntingtin ; HAP 1 binds more tightly to huntingtin with an expanded glutamine repeat than to wild type huntingtin . ^^^ Here , we report the cloning of a human HAP 1 homologue ( hHAP ) that shares 62 % identity with rat HAP 1 over its entire sequence and 82 % amino acid identity in the putative huntingtin binding region . ^^^ Despite similar binding properties of rat HAP 1 and hHAP , differences in the sequences and expression of hHAP may contribute to a specific role for its interaction with huntingtin in humans . . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| HAP 1 localization was also determined in human postmortem tissue from control and Huntington ' s disease ( HD ) cases by light microscopic immunocytochemistry . ^^^ Our data also suggest , however , that HAP 1 is not present in the abnormal intranuclear and neuritic aggregates containing the N terminal fragment of mutant huntingtin that are found in HD brains . . ^^^ The cellular and subcellular localization of huntingtin associated protein 1 ( HAP 1 ) : comparison with huntingtin in rat and human . ^^^ At the cellular level , the heterogeneity of HAP 1 expression was similar to that of huntingtin ; however , HAP 1 immunoreactivity was more widespread . ^^^ Like huntingtin , HAP 1 is a cytoplasmic protein that associates with microtubules and many types of membranous organelles , including mitochondria , endoplasmic reticulum , tubulovesicles , endosomal and lysosomal organelles , and synaptic vesicles . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| The lowest levels of HAP 1 mRNA expression corresponded with the areas of greatest pathological cell loss in Huntington ' s disease ( HD ) ; the caudate putamen , globus pallidus and neocortex . ^^^ These observations support the suggestion that HAP 1 plays an important role in the neuropathology of HD . . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin has been demonstrated to interact with such proteins as HAP 1 , HIP 1 , microtubules , GADPH , calmodulin , and an ubiquitin conjugating enzyme . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Chromosomal localization of the Huntingtin associated protein ( HAP 1 ) gene in mouse and humans with radiation hybrid and interspecific backcross mapping . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin interacts with the proteins GAPDH , HAP 1 , HIP 1 , HIP 2 , and calmodulin , and a mutant huntingtin is specifically cleaved by the proapoptotic enzyme caspase 3 . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein 1 ( HAP 1 ) binds more tightly to mutant huntingtin , but its function and distribution in neurites are not clear . ^^^ Cotransfection of mutant huntingtin with HAP 1 A in PC 12 cells results in the accumulation of HAP 1 A on huntingtin aggregates and the inhibition of neurite promotion by HAP 1 A . ^^^ This study suggests that HAP 1 A has a function in neuritic development and synaptic function and that mutant huntingtin may alter this function . . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Human huntingtin associated protein ( HAP 1 ) gene : genomic organisation and an intragenic polymorphism . ^^^ The huntingtin associated protein ( HAP 1 ) interacts with the Huntington disease gene product , huntingtin . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Assignment of the huntingtin ( Hdh ) gene , the huntingtin associated protein ( Hap 1 ) gene , and the huntingtin interacting protein ( Hip 1 ) gene to rat chromosomes 14 , 10 , and 12 by radiation hybrid mapping and fluorescent in situ hybridization . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of Huntingtin associated protein 1 ( Hap 1 ) results in postnatal death due to depressed feeding behavior . ^^^ HAP 1 is a huntingtin associated protein that is enriched in the brain . ^^^ Loss of HAP 1 expression did not alter the gross brain expression levels of its interacting partners , huntingtin and p150glued . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein 1 ( HAP 1 ) is a novel protein of unknown function with a higher binding affinity for the mutant form of Huntington ' s disease protein huntingtin . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the effect of mutant huntingtin on HAP 1 and EGFR signaling may contribute to the hypothalamic neurodegeneration and loss of body weight in HD . . ^^^ Here , we show that huntingtin associated protein 1 ( HAP 1 ) , which is involved in intracellular trafficking of epidermal growth factor receptor ( EGFR ) , is highly expressed in the hypothalamus . ^^^ Inhibition of HAP 1 expression decreases EGFR signaling and cell viability , whereas overexpression of HAP 1 enhances this signaling activity and inhibits mutant huntingtin mediated cytotoxicity . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Subcellular fractionation and electron microscopy revealed that mutant huntingtin is co localized with huntingtin associated protein 1 ( HAP 1 ) in axonal terminals in the brains of HD transgenic mice . ^^^ Mutant huntingtin binds more tightly to synaptic vesicles than does normal huntingtin , and it decreases the association of HAP 1 with synaptic vesicles in HD mouse brains . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein 1 ( HAP 1 ) was identified as an interactor of the gene product ( Huntingtin ) responsible for Huntington ' s disease and found to be a core component of the stigmoid body . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Htt associated protein 1 ( HAP 1 ) was the first identified Htt binding partner . ^^^ Here we took advantage of mice with targeted disruption of both HAP 1 alleles ( HAP 1 / ) to investigate the role of HAP 1 in functional interactions between Htt and InsP3R1 . ^^^ We determined that : ( 1 ) HAP 1 is expressed in the MSN ; ( 2 ) HAP1A facilitates functional effects of Htt and Htt ( exp ) on InsP3R1 in planar lipid bilayers ; ( 3 ) HAP 1 is required for changes in MSN basal Ca2+ levels resulting from Htt or Htt ( exp ) overexpression ; ( 4 ) HAP 1 facilitates potentiation of InsP3R1 mediated Ca2+ release by Htt ( exp ) in mouse MSN . ^^^ Our present results indicate that HAP 1 plays an important role in functional interactions between Htt and InsP3R1 . . ^^^ HAP 1 facilitates effects of mutant huntingtin on inositol 1 , 4 , 5 trisphosphate induced Ca release in primary culture of striatal medium spiny neurons . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein 1 ( Hap 1 ) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation . ^^^ Huntingtin associated protein 1 ( Hap 1 ) is the first huntingtin interacting protein identified in a yeast two hybrid screen . ^^^ Furthermore , no synergism was observed between Hap 1 and huntingtin mutation during mouse development . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| The higher expression levels of these molecules in nNOS IN when compared with MSN together with an association of nNOS , NR2D and HAP 1 in a protein complex with PSD 95 suggest that these proteins may be involved in protective pathways that contribute to the resistance of this interneuron population to neurodegeneration in HD . . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Several studies suggest that huntingtin and its associated protein HAP 1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein 1 ( HAP 1 ) was initially identified as an interacting partner of huntingtin , the Huntington disease protein . ^^^ Unlike huntingtin that is ubiquitously expressed throughout the brain and body , HAP 1 is enriched in neurons , suggesting that its dysfunction could contribute to Huntington disease neuropathology . ^^^ Growing evidence has demonstrated that HAP 1 and huntingtin are anterogradely transported in axons and that the abnormal interaction between mutant huntingtin and HAP 1 may impair axonal transport . ^^^ Huntingtin associated protein 1 ( HAP 1 ) was initially identified as an interacting partner of huntingtin , the Huntington disease protein . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin mediated transport involves Huntingtin Associated Protein 1 ( HAP 1 ) and the p 150 ( Glued ) subunit of dynactin , an essential component of molecular motors . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| There is growing evidence that huntingtin associated protein 1 ( HAP 1 ) also interacts with microtubule dependent transporters and is involved in intracellular trafficking . ^^^ Mutant huntingtin also reduces the association of HAP 1 with dynactin p 150 and kinesin light chain and thereby decreases the intracellular level of TrkA . ^^^ These findings suggest that HAP 1 trafficking is critical for the stability of TrkA and neurite function , both of which can be attenuated by mutant huntingtin . . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin associated protein 1 ( HAP 1 ) , an interactor of huntingtin , has been known as an essential component of the stigmoid body ( STB ) and recently reported to play a protective role against neurodegeneration in Huntington ' s disease ( HD ) . ^^^ Huntingtin associated protein 1 ( HAP 1 ) interacts with androgen receptor ( AR ) and suppresses SBMA mutant AR induced apoptosis . ^^^ Huntingtin associated protein 1 ( HAP 1 ) , an interactor of huntingtin , has been known as an essential component of the stigmoid body ( STB ) and recently reported to play a protective role against neurodegeneration in Huntington ' s disease ( HD ) . ^^^ |
|
| Interacting proteins: P54257 and P42858 |
Pubmed |
SVM Score :0.0 |
| Huntingtin and huntingtin associated protein 1 influence neuronal calcium signaling mediated by inositol ( 1 , 4 , 5 ) triphosphate receptor type 1 . ^^^ |
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