| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| Indeed , upon IGF 1 activation , Akt phosphorylates polyQ huntingtin at serine 421 and abrogates its toxicity . ^^^ |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| In clones carrying the mutated Huntingtin , both NGF and EGF receptor mediated activation of mitogen activated protein kinase , c Jun N terminal kinase , and Akt are significantly attenuated , and NGF receptor mediated neurite outgrowth is blocked . ^^^ |
|
| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| The IGF 1 / Akt pathway is neuroprotective in Huntington ' s disease and involves Huntingtin phosphorylation by Akt . ^^^ In the search for neuroprotective factors in Huntington ' s disease , we found that insulin growth factor 1 via activation of the serine / threonine kinase Akt / PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded polyglutamine stretch . ^^^ The IGF 1 / Akt pathway has a dual effect on huntingtin induced toxicity , since activation of this pathway also results in a decrease in the formation of intranuclear inclusions of mutant huntingtin . ^^^ We demonstrate that huntingtin is a substrate of Akt and that phosphorylation of huntingtin by Akt is crucial to mediate the neuroprotective effects of IGF 1 . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| Increased clearance of mutant huntingtin by raised glucose ( 8 g / l ) and 2DOG correlated with increased autophagy and reduced phosphorylation of mTOR , S6K1 and Akt . ^^^ Thus , raised intracellular glucose / glucose 6 phosphate levels reduce mutant huntingtin toxicity by increasing autophagy via mTOR and possibly Akt . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of arfaptin 2 at Ser 260 by Akt Inhibits PolyQ huntingtin induced toxicity by rescuing proteasome impairment . ^^^ This neuroprotective effect involves the phosphorylation of huntingtin at Ser ( 421 ) by the prosurvival kinase Akt ( Humbert , S . , Bryson , E . ^^^ Here , we report that Akt inhibits polyQ huntingtin induced toxicity in the absence of phosphorylation of huntingtin at Ser ( 421 ) , suggesting that Akt also acts on other downstream effector ( s ) to prevent neuronal death in HD . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| Huntingtin is phosphorylated on serine 421 ( S 421 ) by the pro survival signaling protein kinase Akt ( PKB ) and this has been previously shown to be protective against the toxicity of polyglutamine expanded htt in cell culture . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| The insulin like growth factor 1 ( IGF 1 ) / Akt pathway plays a crucial role in Huntington ' s disease by phosphorylating the causative protein , polyQ huntingtin , and abolishing its toxic properties [ Humbert et al . ( 2002 ) Dev . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| Insulin like growth factor 1 acting through the prosurvival kinase Akt mediates the phosphorylation of huntingtin at S 421 and inhibits the toxicity of polyQ expanded huntingtin in cell culture , suggesting that compounds enhancing phosphorylation are of therapeutic interest . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| Carcasses of 181 barrows , representing five genotypes , 1 ) H 10 HD , 2 ) SYN , 3 ) HD 10 L [ YD ] , 4 ) L 10 YD , and 5 ) Y 10 L ( H = Hampshire , D = Duroc , SYN = synthetic terminal sire line , L = Landrace , and Y = Yorkshire ) , and two levels of ractopamine ( RAC ) treatment ( 0 and 20 ppm ) were completely dissected and the data were used to examine genotype and treatment ( RAC ) biases in estimation of fat standardized lean weight and to evaluate accuracies and precisions realized by use of equations based on variables derived from different technologies . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| In the RAC # 1 trial of stage 1 and 2 HD we demonstrated that involved field radiotherapy plus six courses of MOPP chemotherapy improved relapse free survival compared to standard radiotherapy alone ( P = 0 . 12 ) , especially in patients with B symptoms ( P less than 0 . 03 ) or mediastinal disease ( P = 0 . 08 ) . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| Inhibition of PI3K / Akt increased spontaneous apoptosis more in LD and H2O2 induced apoptosis more in HD , diminishing the density dependence of apoptosis . p 38 MAPK inhibition reduced H2O2 induced apoptosis more in LD , diminishing the density dependence of H2O2 induced apoptosis without altering that of spontaneous apoptosis . ^^^ Akt level and activity and Hsp 72 level were increased in HD , but decreased in MD and LD cells , by H2O2 , and the active p 38 MAPK was enhanced by H2O2 in all groups . ^^^ |
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| Interacting proteins: P42858 and P31749 |
Pubmed |
SVM Score :0.0 |
| CD 150 is linked to ERK and Akt pathways in HD cell lines . ^^^ Our data suggest that CD 150 SH2D1A association play decisive role in Akt signaling upon CD 150 ligation in HD cell lines . ^^^ CD 150 mediated Akt activation in HD cell lines , similarly to DT 40 model system , is SHIP independent . . ^^^ |
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