| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| To date there have been no studies examining the role of the ICE / Ced 3 family of proteins , in particular CPP 32 , in HD . ^^^ |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| Sixty five consecutive patients , 22 with primary refractory HD and 43 with relapsed HD , were treated with 2 biweekly cycles of ifosfamide , carboplatin , and etoposide ( ICE ) . ^^^ |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| ICE dependent processing of inactive proIL 1beta into biologically active mIL 1beta is reduced in PD patients , but not in HD patients . ^^^ This impaired ability to secrete active mIL 1beta seems to be independent of ICE activity and is normalized when HD patients are switched from Cuprophan to low or high flux polysulfon . ^^^ |
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| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| In the present study we investigated the role of caspase 1 in neurotoxic experimental animal models of Huntington ' s disease ( HD ) by examining whether transgenic mice expressing a caspase 1 dominant negative mutant are resistant to malonate and 3 nitropropionic acid ( 3 NP ) neurotoxicity . ^^^ These results provide further evidence of a functional role for caspase 1 in both malonate and 3 NP mediated neurotoxin models of HD . . ^^^ |
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| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| Inhibiting caspase 1 can prolong the survival of these HD mice . ^^^ We propose that the increased level of caspase 1 induced by intranuclear huntingtin contributes to HD associated cell death . . ^^^ Intranuclear huntingtin increases the expression of caspase 1 and induces apoptosis . ^^^ We show that intranuclear huntingtin increases the expression of caspase 1 , which may in turn activate caspase 3 and trigger apoptosis . ^^^ |
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| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| We have demonstrated in a transgenic HD mouse model that caspase 1 and caspase 3 are transcriptionally up regulated and activated . ^^^ Underscoring the relevancy of these findings , recent results suggest that caspase 1 is activated in brains of humans with HD . ^^^ Nuclear translocation of mutant htt in vitro up regulates expression of the cell death gene caspase 1 . ^^^ |
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| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| In contrast , timing of early disease events was not altered by normal huntingtin or by mutant caspase 1 , two proteins shown to reduce inclusions and glutamine toxicity in other HD models . ^^^ |
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| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| HT and NE , but not HD and NI , caused rapid and transient induction of caspase 3 / CPP32 activity , but not caspase 1 activity , according to the cleavage of caspase 3 substrates poly ( ADP ribose ) polymerase and D 4 GDI proteins , the appearance of cleaved caspase 3 fragments detected in HT or NE , but not in HD or NI treated HL 60 cells . ^^^ |
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| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| Caspase 1 activation is an early event in models of Huntington ' s disease ( HD ) . ^^^ We demonstrate in models of HD that caspase 1 activation results from dysregulation of caspase 1 activation pathways . ^^^ |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29466 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|