| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| Moreover , the mutant huntingtin amino terminus is capable of recruiting into aggregates normal glutamine tract proteins , such as the amino terminal segments of both normal huntingtin and of TATA binding protein ( TBP ) . ^^^ They also contain non huntingtin protein , as evidenced by immunostaining for TBP . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| A proportion of TBP alleles fall within the range of glutamine length that causes neurodegeneration when located in the huntingtin protein . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , the wild type TBP repeat length ranges from 25 to 42 , and in Caucasian populations the most common allele is 38 , a size large enough to cause HD if within the huntingtin protein . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| We show , in vitro and in cells , that monomers or small soluble oligomers of huntingtin exon 1 accumulate in the nucleus and inhibit the function of TBP in a polyQ dependent manner . ^^^ Interaction of toxic huntingtin with the benign polyQ repeat of TBP structurally destabilizes the transcription factor , independent of the formation of insoluble coaggregates . ^^^ Hsp70 / Hsp40 chaperones interfere with the conformational change in mutant huntingtin and inhibit the deactivation of TBP . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we examined the expression and localization of the polyglutamine containing or glutamine rich transcription factors TBP , CBP and Sp 1 in HD mouse models . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| Eleven cases of tuberculous peritonitis ( TBP ) in hemodialysis ( HD ) and continuous ambulatory peritoneal dialysis ( CAPD ) patients at the Kaohsiung Veterans General Hospital in Kaohsiung , Taiwan between 1991 and 2000 were studied retrospectively ( six cases in the HD group and five cases in the CAPD group ) The diagnosis of TBP was established by either positive ascite tuberculosis ( TB ) culture or biopsy proven chronic granulomatous inflammation . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| We extracted genomic DNA from peripheral white blood cells , and performed genetic tests for Huntington disease ( HD ) , dentatorubral pallidoluysian atrophy ( DRPLA ) , Huntington disease like 1 ( HDL 1 ) , HDL 2 and spinocerebellar ataxia type 17 ( SCA 17 ) . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| Given the partial clinical overlap of SCA 17 , DRPLA and neuroferritinopathy with HD , their causative genes ( TBP , ATN 1 , and FTL , respectively ) were also analysed . ^^^ |
|
| Interacting proteins: P42858 and P20226 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that both gene specific activator protein Sp 1 and selective components of the core transcription apparatus , including TFIID and TFIIF , are direct targets inhibited by mutant htt in a polyglutamine dependent manner . ^^^ |
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