| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| Additional studies of green fluorescent protein tagged cAMP response element binding protein coexpressed with either of two mutant polyglutamine proteins , ataxin 3 and huntingtin , support a model of disease in which coaggregation of transcriptional components contributes to pathogenesis . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| Increased cAMP response element binding protein ( CREB ) phosphorylation and elevated levels of the CREB regulated gene product , CCAAT / enhancer binding protein beta , were also found in HD mice . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| Several transcription factors that have been shown to interact with mutant huntingtin , including Sp 1 , neuron restrictive silencing factor , TATA binding protein and cAMP response element binding protein , are unlikely to be involved in mutant huntingtin induced PDE10A2 transcriptional dysregulation . . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the A2A R using CGS 21680 , forskolin , and a constitutively active cAMP response element binding protein ( CREB ) mutant elevated the reduced promoter activity of the A2A R gene by mutant Htt . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| Expanded polyglutamine repeats have been proposed to cause neuronal degeneration in Huntington ' s disease ( HD ) and related disorders , through abnormal interactions with other proteins containing short polyglutamine tracts such as the transcriptional coactivator CREB binding protein , CBP . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| There is growing evidence that truncated forms of mutant Htt in the nucleus influence gene transcription by binding to proteins such as CREB binding protein ( CBP ) response element binding protein binding protein , N COR , glyceraldehyde 3 phosphate dehydrogenase , and p 53 . p 53 regulates the transcription of various mitochondrial proteins which may underlie the mitochondrial abnormalities , especially the vulnerability to mitochondrial depolarization , seen in HD tissues . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| Recent evidence has shown that the activity of cAMP responsive element binding protein ( CREB ) and of CREB binding protein ( CBP ) is decreased in Huntington ' s disease ( HD ) [ Steffan et al . ( 2000 ) Proc . ^^^ Our study aimed to investigate the distribution of CREB in the neuronal subpopulations of the striatum in normal rats compared to the HD model of quinolinic acid lesion . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| Transfection of mutant huntingtin causes cell toxicity and depletion of CREB binding protein ( CBP ) or its recruitment into huntingtin aggregates . ^^^ |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16220 and P42858 |
Pubmed |
SVM Score :0.0 |
| NA |
|